Detailed information NTG0285215

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: C5Y81_RS09515
• Genome accession: NZ_CP028470
• Coordinates: 1894439..1895482 (-)
• Length: 347 a.a.
• NCBI ID: WP_110164955.1
• Uniprot ID: A0A1L6C0B3
• Organism: Staphylococcus aureus strain IT4-R
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1889439..1900482

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C5Y81_RS09485 (C5Y81_09485)	-	1889860..1891116 (-)	1257	WP_075583716.1	aminopeptidase	-
C5Y81_RS09490 (C5Y81_09490)	-	1891119..1891319 (-)	201	WP_000180460.1	DUF1128 family protein	-
C5Y81_RS09495 (C5Y81_09495)	-	1891466..1891930 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
C5Y81_RS09500 (C5Y81_09500)	-	1891937..1892212 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
C5Y81_RS09505 (C5Y81_09505)	-	1892490..1893707 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
C5Y81_RS09510 (C5Y81_09510)	vraR	1893820..1894449 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
C5Y81_RS09515 (C5Y81_09515)	vraS	1894439..1895482 (-)	1044	WP_110164955.1	sensor histidine kinase	Regulator
C5Y81_RS09520 (C5Y81_09520)	liaF	1895479..1896180 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
C5Y81_RS09525 (C5Y81_09525)	-	1896195..1896581 (-)	387	WP_001110179.1	hypothetical protein	-
C5Y81_RS09530 (C5Y81_09530)	map	1896798..1897556 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
C5Y81_RS09535 (C5Y81_09535)	-	1898085..1899071 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
C5Y81_RS09545 (C5Y81_09545)	-	1899502..1899915 (-)	414	WP_001670387.1	hypothetical protein	-
C5Y81_RS09550 (C5Y81_09550)	-	1899944..1900054 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40056.57 Da
• Isoelectric Point: 6.0577

>NTDB_id=285215 C5Y81_RS09515 WP_110164955.1 1894439..1895482(-) (vraS) [Staphylococcus aureus strain IT4-R]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGIRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=285215 C5Y81_RS09515 WP_110164955.1 1894439..1895482(-) (vraS) [Staphylococcus aureus strain IT4-R]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTATACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-338)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A1L6C0B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997