Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   SK637_RS09460 Genome accession   NZ_CP028415
Coordinates   1897197..1899629 (-) Length   810 a.a.
NCBI ID   WP_033689564.1    Uniprot ID   -
Organism   Streptococcus mitis strain SK637     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1892197..1904629
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS09430 (SK637_01838) - 1892861..1893088 (+) 228 Protein_1765 tRNA dihydrouridine synthase DusB -
  SK637_RS09435 (SK637_01839) - 1893159..1893857 (-) 699 WP_033689558.1 hypothetical protein -
  SK637_RS09440 (SK637_01840) - 1894136..1894366 (+) 231 WP_033689560.1 hypothetical protein -
  SK637_RS09445 (SK637_01841) - 1894442..1895215 (-) 774 WP_033689561.1 NUDIX domain-containing protein -
  SK637_RS09450 (SK637_01842) pnuC 1895217..1895996 (-) 780 WP_000736873.1 nicotinamide riboside transporter PnuC -
  SK637_RS09455 (SK637_01843) - 1896006..1897064 (-) 1059 WP_033689562.1 AAA family ATPase -
  SK637_RS09460 (SK637_01844) clpC 1897197..1899629 (-) 2433 WP_033689564.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SK637_RS09465 (SK637_01845) - 1899631..1900089 (-) 459 WP_033689565.1 CtsR family transcriptional regulator -
  SK637_RS09470 (SK637_01846) - 1900208..1900936 (-) 729 WP_020902628.1 ABC transporter ATP-binding protein -
  SK637_RS09475 (SK637_01847) - 1900936..1901943 (-) 1008 WP_033689566.1 ABC transporter substrate-binding protein -
  SK637_RS09480 (SK637_01848) - 1901982..1902740 (-) 759 WP_161970147.1 ABC transporter permease -
  SK637_RS09485 (SK637_01849) - 1902703..1902993 (-) 291 WP_033689568.1 thiamine-binding protein -
  SK637_RS09490 (SK637_01850) cbpD 1903247..1904365 (-) 1119 WP_033689569.1 choline binding-anchored murein hydrolase CbpD -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90115.86 Da        Isoelectric Point: 6.0165

>NTDB_id=284737 SK637_RS09460 WP_033689564.1 1897197..1899629(-) (clpC) [Streptococcus mitis strain SK637]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SHRLQVLFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIATLRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSGLSPADKALIDGKWKQAAQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANKGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGNTLKIGV
KAGQLKFDIA

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=284737 SK637_RS09460 WP_033689564.1 1897197..1899629(-) (clpC) [Streptococcus mitis strain SK637]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGCCATTTTGGAGCTCGTTACCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTGGCAGGGGCAACTTTAAATGATTATCCATATGAGA
TGGATCGTTTAGAAGAAGTTGCTTTGGAGTTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTC
TCTCATCGTTTGCAGGTCCTTTTTGACGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTGCTAGGGACAGAGCA
TGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACA
AGAAGGATCAGGTTAAGATTGCTACCCTTCGTCGAAATTTAGAAGAACGAGCAGGTTGGACTCGTGAAGATCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGATAAGCAAAATTCTATGGCTAATATGATGGGCATGCCCCAGACTCCGAGTGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATCGGTCGAGATAAGG
AAATCTCGCGTATGATTCAAATCTTGAGCCGTAAAACCAAGAATAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA
ACAGCCTTGGCGCTTGGGCTTGCCCAGCGTATTGCTAGTGGTGATGTACCTGCAGAAATGGCTAAGATGCGCGTGTTAGA
GCTTGATTTGATGAATGTTGTTGCAGGGACACGTTTCCGTGGTGACTTTGAAGAACGCATGAACAATATCATCAAGGATA
TTGAAGAAGATGGCCAAGTCATCCTCTTTATCGATGAACTTCATACCATCATGGGTTCTGGTAGTGGGATTGACTCAACT
CTAGATGCGGCCAATATCTTGAAGCCAGCCTTGGCGCGTGGAACTTTGAGAACAGTTGGTGCGACCACTCAGGAAGAATA
CCAAAAACATATCGAAAAAGATGCAGCCCTTTCTCGTCGTTTCGCAAAAGTGACGATTGAAGAGCCAAGTGTGGCAGACA
GCATGACCATTTTACAAGGCTTGAAGGCGACTTATGAGAAACATCACCGTGTGCAAATCACAGATGAAGCGGTTGAAACA
GCTGTTAAGATGGCTCATCGTTATTTGACTAGTCGTCACTTGCCAGACTCTGCTATTGATCTCTTGGATGAAGCAGCAGC
AACAGTGCAAAATAAGGCTAAGCATGTAAAAGCAGATGATTCAGGTTTGAGTCCAGCTGACAAGGCCTTGATAGATGGCA
AGTGGAAACAGGCAGCCCAGCTAATCGCAAAAGAAGAGGAAGTGCCTGTCTATAAAGACTTGGTGACAGAGTCTGATATT
TTGACCACCTTGAGTCGCTTGTCAGGTATTCCAGTCCAAAAACTGACTCAGACAGACGCTAAGAAATACCTGAATTTGGA
AGCTGAATTGCACAAACGTGTCATCGGTCAAGATCAAGCTGTTTCAAGCATTAGCCGTGCGATTCGCCGCAACCAGTCAG
GGATTCGTAGTCATAAGCGTCCGATTGGTTCCTTTATGTTCCTAGGGCCTACAGGTGTCGGTAAGACCGAATTGGCCAAG
GCTTTGGCAGAAGTTCTTTTTGACGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTTGCAGC
CAGTCGTCTCAATGGAGCTCCTCCGGGTTATGTGGGTTATGAAGAAGGTGGGGAGTTGACCGAGAAGGTTCGCAATAAAC
CATACTCTGTTCTCCTCTTTGATGAGGTAGAAAAAGCTCACCCAGACATCTTTAATGTTCTCTTGCAGGTCTTGGATGAC
GGTGTCTTAACCGATAGCAAGGGACGCAAGGTTGACTTTTCAAATACTATTATCATAATGACGTCAAACCTTGGTGCGAC
AGCCCTTCGGGATGATAAGACTGTCGGATTTGGAGCTAAGGACATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAGCTGAAAAAAGCTTATAGACCTGAGTTTATTAATCGTATTGATGAAAAGGTGGTCTTCCATAGCCTGTCTAGC
GATCATATGCAGGAAGTGGTGAAGATTATGGTCAAACCTTTAGTGGCAAGTTTGGCTGAAAAAGGCATTGACTTGAAATT
ACAAGCTTCAGCACTGAAATTGTTGGCAAATAAAGGATATGACCCAGAGATGGGGGCTCGTCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAGGACAAGTTGGCAGAACTTCTTCTTAAGGGAGATTTGGTGGCAGGTAACACACTTAAGATTGGTGTC
AAAGCAGGCCAGTTAAAATTTGATATTGCATAA

Domains

Predicted by InterproScan.

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-139)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

AAA lid domain (AAA_lid_9)

(370-439)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae D39

99.012

100

0.99
  clpC Streptococcus pneumoniae TIGR4

99.012

100

0.99
  clpC Streptococcus pneumoniae Rx1

99.012

100

0.99
  clpC Streptococcus mutans UA159

67.159

100

0.674
  clpC Streptococcus thermophilus LMD-9

66.339

100

0.667
  clpC Streptococcus thermophilus LMG 18311

66.216

100

0.665
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.854

100

0.5
  clpC Bacillus subtilis subsp. subtilis str. 168

45.241

99.877

0.452
  clpE Streptococcus mutans UA159

49.355

76.543

0.378
  clpE Streptococcus pneumoniae Rx1

47.293

77.531

0.367
  clpE Streptococcus pneumoniae D39

47.293

77.531

0.367
  clpE Streptococcus pneumoniae R6

47.293

77.531

0.367
  clpC Lactococcus lactis subsp. cremoris KW2

46.955

77.037

0.362
  clpE Streptococcus pneumoniae TIGR4

45.768

78.765

0.36

Multiple sequence alignment