Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   SK637_RS03905 Genome accession   NZ_CP028415
Coordinates   711495..713753 (-) Length   752 a.a.
NCBI ID   WP_033688622.1    Uniprot ID   -
Organism   Streptococcus mitis strain SK637     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 706495..718753
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS03885 (SK637_00756) ezrA 708014..709741 (+) 1728 WP_000016768.1 septation ring formation regulator EzrA -
  SK637_RS03890 (SK637_00757) - 709787..710419 (-) 633 WP_000502302.1 GNAT family N-acetyltransferase -
  SK637_RS03895 (SK637_00758) - 710555..710854 (-) 300 WP_033688621.1 DUF1827 family protein -
  SK637_RS03900 (SK637_00759) - 710913..711365 (-) 453 WP_000013084.1 NUDIX hydrolase -
  SK637_RS03905 (SK637_00760) clpE 711495..713753 (-) 2259 WP_033688622.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SK637_RS03910 (SK637_00761) - 713982..714212 (-) 231 WP_000443570.1 DUF1797 family protein -
  SK637_RS03915 (SK637_00762) - 714403..715086 (+) 684 WP_033688624.1 amino acid ABC transporter permease -
  SK637_RS03920 (SK637_00763) - 715086..715820 (+) 735 WP_033688625.1 amino acid ABC transporter ATP-binding protein -
  SK637_RS03925 (SK637_00764) - 715998..716855 (+) 858 WP_033688627.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  SK637_RS03930 (SK637_00765) - 716993..717814 (+) 822 WP_000601058.1 hypothetical protein -
  SK637_RS03935 (SK637_00766) - 717828..718679 (+) 852 WP_033688629.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83809.21 Da        Isoelectric Point: 5.2358

>NTDB_id=284704 SK637_RS03905 WP_033688622.1 711495..713753(-) (clpE) [Streptococcus mitis strain SK637]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPTPP
TQSGGGYGGNGGYGSQNRESAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKTSEKEV

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=284704 SK637_RS03905 WP_033688622.1 711495..713753(-) (clpE) [Streptococcus mitis strain SK637]
ATGCTTTGTCAAAACTGTAAAATCAATGACTCAACAATTCATCTTTATACCAATCTCAATGGAAAGCAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAGACAGATCCTAACAATAGCCTCTTTAAAGGTATGACGGATCTGAATAATC
GTGACTTTGATCCCTTTGGTGATTTCTTCAATGACCTAAACAATTTTAGACCTTCTAGCAATACTCCTCCGACTCCTCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGAATCTGCTCAAACTCCGCCTCCAAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATCAACGTAACTGAAATTGCCCGTCGTGGAGATATTGACCCCGTTATTG
GGCGCGACGATGAAATTATCCGTGTTATTGAGATTCTCAATCGCAGAACAAAGAATAATCCTGTTCTTATCGGTGAACCA
GGTGTCGGAAAAACTGCCGTTGTCGAAGGTCTAGCTCAGAAAATCGTTGATGGCGATGTTCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTAGATGTAGTTAGCTTGGTTCAAGGAACGGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGAAAACGTGAGGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTCGGTGCTGGTTCTGCA
GGCGATGGCAATATGGATGCAGGAAATATCCTCAAGCCCGCCCTTGCTCGTGGGGAACTGCAATTGGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCTTAGAGCGTCGTATGCAACCTGTTAAGGTCGATGAACCAACAG
TGGAGGAAACAATTACTATCCTCAAAGGCATTCAAAAGAAATACGAAGACTACCACCACGTTCAGTATACCGATGCTGCT
ATCGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTACCAGACAAAGCCATCGACCTCCTGGATGA
AGCTGGTTCTAAAATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATCGATCAGCGCTTGATTGAGGCTGAAAATC
TTAAATCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCCGCCTACTTCCGTGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGGTCACAGACCAGGATACTCCTATCATCAGTGAAAAAACCATTGAGCATATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTTATCCATCTAGCAGAAGACCTCAAGTCTCATGTTATTG
GACAAGACGATGCTGTCGATAAGATTGCCAAGGCTATTCGCCGGAATCGTGTCGGTCTCGGTACGCCTAACCGTCCAATT
GGAAGCTTCCTCTTCGTCGGACCAACTGGCGTCGGTAAGACAGAACTTTCCAAACAACTAGCTATCGAACTCTTTGGTTC
TGCTGACAGTATGATTCGCTTTGACATGAGTGAATATATGGAAAAACACAGTGTGGCTAAGTTGGTCGGTGCCCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGGCAATTAACTGAAAAAGTTCGCCGCAATCCATATTCTCTTATACTTCTCGATGAA
GTAGAGAAAGCCCATCCAGATGTTATGCACATGTTCCTCCAGGTCTTAGACGATGGTCGTTTGACAGATGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATCATCATGACTTCAAATGCAGGTACAGGTAAGGCAGAAGCCAGCGTTGGATTTG
GGGCAGCTCGCGAAGGACGTACCAACTCTGTTCTTGGTGAACTCGGTAACTTTTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGACAACCTCCTTCAGATTGTCGAACTTATGCTTGCAGACGTTAACAA
GCGCCTTTCTAGCAACAACATTCATTTAGATGTAACTGAAAAGGTCAAGGAAAAATTGGTTGACCTCGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGTACTATTCAAGACTATATTGAGGACGCAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGACCTAAAGGCAGTGATGACTAGCAAGGGCAACATTCAAATCAAATCTGCCAAAAAAGCTGAAGTAAAAAC
TTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

AAA lid domain (AAA_lid_9)

(293-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

98.535

99.867

0.984
  clpE Streptococcus pneumoniae D39

98.535

99.867

0.984
  clpE Streptococcus pneumoniae R6

98.535

99.867

0.984
  clpE Streptococcus pneumoniae TIGR4

98.402

99.867

0.983
  clpE Streptococcus mutans UA159

82.869

100

0.83
  clpC Lactococcus lactis subsp. cremoris KW2

75.429

100

0.759
  clpC Bacillus subtilis subsp. subtilis str. 168

51.565

89.229

0.46
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.847

83.378

0.399
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus mutans UA159

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386

Multiple sequence alignment