Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SM12261_RS03850 Genome accession   NZ_CP028414
Coordinates   709819..710493 (+) Length   224 a.a.
NCBI ID   WP_000590639.1    Uniprot ID   A0A419RXM2
Organism   Streptococcus mitis NCTC 12261     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 704819..715493
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS03830 (SM12261_0743) - 705643..705879 (+) 237 WP_000141913.1 DUF2829 domain-containing protein -
  SM12261_RS03835 (SM12261_0744) - 705872..706570 (+) 699 WP_000198458.1 3-oxoacyl-ACP reductase -
  SM12261_RS03840 (SM12261_0745) - 706601..707041 (+) 441 WP_000188805.1 ASCH domain-containing protein -
  SM12261_RS03845 (SM12261_0746) - 707164..709710 (+) 2547 WP_001149091.1 M1 family metallopeptidase -
  SM12261_RS03850 (SM12261_0747) ciaR 709819..710493 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  SM12261_RS03855 (SM12261_0748) ciaH 710483..711817 (+) 1335 WP_000491799.1 two-component system sensor histidine kinase CiaH Regulator
  SM12261_RS03860 (SM12261_0749) - 711851..712138 (-) 288 WP_001145221.1 DUF3270 domain-containing protein -
  SM12261_RS03865 (SM12261_0750) - 712278..713207 (+) 930 WP_000411171.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=284637 SM12261_RS03850 WP_000590639.1 709819..710493(+) (ciaR) [Streptococcus mitis NCTC 12261]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=284637 SM12261_RS03850 WP_000590639.1 709819..710493(+) (ciaR) [Streptococcus mitis NCTC 12261]
ATGATAAAAATCTTATTAGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGTGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTCGATTTAATGT
TACCTGAAAAAAATGGCTTTCAAGTCTTGAAAGAATTGCGTGAAAAAGGAATTACGACACCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAATTGGGAGCAGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCGCTTCTCAAACGTTCAGGTAAATTTAATGAAAACACCTTGACTTATGGAAATATTGTGG
TTAATTTGTCAACCAATACTGTTAAAGTCGAAGATACTCCTGTCGAATTGCTAGGTAAAGAGTTTGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGACACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RXM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment