Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   C9J78_RS08100 Genome accession   NZ_CP028165
Coordinates   1572498..1573847 (-) Length   449 a.a.
NCBI ID   WP_000806246.1    Uniprot ID   -
Organism   Staphylococcus aureus strain CFSAN064037     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 1562300..1573847 1572498..1573847 within 0


Gene organization within MGE regions


Location: 1562300..1573847
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C9J78_RS08045 (C9J78_08050) mecC 1562300..1564297 (-) 1998 WP_000725529.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC -
  C9J78_RS08050 (C9J78_08055) - 1564398..1566152 (+) 1755 WP_000941320.1 BlaR1 family beta-lactam sensor/signal transducer -
  C9J78_RS08055 (C9J78_08060) mecI 1566149..1566523 (+) 375 WP_107240667.1 mecC-type methicillin resistance repressor MecI -
  C9J78_RS14115 - 1566597..1566773 (-) 177 WP_158306650.1 hypothetical protein -
  C9J78_RS08060 (C9J78_08065) - 1566779..1567081 (-) 303 WP_000073847.1 hypothetical protein -
  C9J78_RS08065 (C9J78_08070) - 1567101..1567568 (-) 468 WP_000932101.1 hypothetical protein -
  C9J78_RS08070 (C9J78_08075) - 1567585..1568469 (-) 885 WP_000373152.1 HTH domain-containing protein -
  C9J78_RS08075 (C9J78_08080) - 1568667..1569086 (-) 420 WP_046597257.1 RadC family protein -
  C9J78_RS08080 (C9J78_08085) - 1569107..1569613 (-) 507 WP_001179666.1 DUF1643 domain-containing protein -
  C9J78_RS08085 (C9J78_08090) - 1569629..1569940 (-) 312 WP_001046053.1 DUF960 family protein -
  C9J78_RS08090 (C9J78_08095) - 1570036..1570374 (-) 339 WP_000171558.1 SAUGI family uracil-DNA glycosylase inhibitor -
  C9J78_RS08095 (C9J78_08100) ccrB 1570849..1572477 (-) 1629 WP_001186597.1 cassette chromosome recombinase CcrB Machinery gene
  C9J78_RS08100 (C9J78_08105) ccrA 1572498..1573847 (-) 1350 WP_000806246.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52155.87 Da        Isoelectric Point: 10.0227

>NTDB_id=281951 C9J78_RS08100 WP_000806246.1 1572498..1573847(-) (ccrA) [Staphylococcus aureus strain CFSAN064037]
MKQAIGYLRQSTLKQQSLSAQKQTIKTLAEKHNIQHIIFYSDKQSGRTENRTGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQTYHVHILSVHDGYFDMNKAFDRLKLNIFISLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYH
NGTFMINNIEAPTVKAVFSYYLQGYGYKKIAQYLEDDEKFINRKPYQVRNIIMNPNYCGRVINQYGRYDNMCPSIVSTSI
YEQAQAIRSQKQLKRTSSANQLKQKIKCPYCGSTLTNITIRKKHRTLRYYVCPQNMNASRFVCEFKGINAQSLEASVLVT
CQDFFQNQHLYSKINHTIQKRLKKQKDIEAKSTVTQEQLIEKLAQGKIDAETFREQTQSFRQQSKPITSIHTHQIQKALQ
NVIQQSFTLNMLYPYIDEIHITKSKTLTGIYFKNEPLNIVNQTAQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=281951 C9J78_RS08100 WP_000806246.1 1572498..1573847(-) (ccrA) [Staphylococcus aureus strain CFSAN064037]
ATGAAACAAGCAATAGGTTATCTACGTCAAAGTACACTCAAGCAACAATCACTCTCGGCTCAGAAACAAACCATCAAGAC
ATTAGCCGAAAAACATAATATTCAACACATCATCTTTTATAGCGATAAGCAATCAGGACGTACTGAAAATCGAACAGGCT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATGTGACGTATTATGTTGCTATCGTCTGAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAACTCATGAAATTATGTCAAACGTATCATGTTCATATCTTAAGTGTTCATGATGGCTACTTCGA
CATGAATAAAGCTTTCGATCGACTAAAACTCAACATTTTCATCAGCTTGGCTGAACTAGAATCAGATAATATTGGAGAAC
AAGTCAAAAATGGCCTTCGGGAAAAAGCAAAACAAGGTAAACTGATTACGACCCATGCACCCTTTGGCTATCACTATCAT
AACGGTACTTTCATGATAAACAACATAGAAGCACCAACCGTAAAAGCTGTATTTAGCTATTATCTTCAAGGCTATGGTTA
TAAAAAAATTGCACAGTACTTAGAAGATGACGAGAAATTCATCAATCGTAAACCCTATCAAGTACGTAATATTATCATGA
ACCCCAATTATTGTGGTCGAGTCATTAATCAATACGGGCGATATGACAACATGTGTCCTTCTATTGTTTCGACAAGTATA
TATGAACAAGCTCAAGCGATACGGTCACAAAAGCAACTCAAACGGACATCATCAGCTAATCAACTCAAACAAAAAATTAA
ATGTCCTTATTGTGGTTCAACGTTGACTAATATAACCATTAGAAAAAAGCACCGCACATTACGTTATTATGTCTGTCCCC
AAAATATGAATGCATCTCGTTTTGTCTGTGAATTCAAAGGAATCAACGCACAATCATTAGAAGCGAGTGTCTTAGTTACA
TGTCAAGACTTCTTTCAAAATCAACATCTGTATTCAAAAATCAACCATACAATCCAAAAACGACTCAAAAAACAAAAAGA
CATAGAAGCTAAAAGTACAGTCACGCAAGAACAACTGATAGAAAAATTAGCCCAAGGTAAAATTGATGCAGAAACATTCA
GAGAACAAACGCAATCATTTCGACAACAGTCAAAACCTATAACATCAATCCATACGCATCAAATTCAAAAGGCTTTACAA
AATGTAATACAGCAAAGTTTCACGTTAAACATGTTGTACCCTTACATCGATGAAATTCATATTACCAAAAGTAAAACGCT
TACGGGTATCTATTTCAAAAATGAACCCTTAAACATCGTCAATCAAACAGCACAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

83.964

100

0.84
  ccrA Staphylococcus aureus N315

77.506

100

0.775

Multiple sequence alignment