Detailed information NTG0280454

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: C7K40_RS06340
• Genome accession: NZ_CP027771
• Coordinates: 1253082..1254119 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain DMG1800716
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1248082..1259119

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C7K40_RS06320 (C7K40_06315)	-	1248832..1249458 (+)	627	WP_002983834.1	A24 family peptidase	-
C7K40_RS06325 (C7K40_06320)	rlmN	1249540..1250619 (-)	1080	WP_023612790.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
C7K40_RS06330 (C7K40_06325)	-	1250623..1251243 (-)	621	WP_002992791.1	YutD family protein	-
C7K40_RS06335 (C7K40_06330)	-	1251691..1252668 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
C7K40_RS06340 (C7K40_06335)	sepM	1253082..1254119 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
C7K40_RS06345 (C7K40_06340)	coaD	1254106..1254597 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
C7K40_RS06350 (C7K40_06345)	rsmD	1254587..1255126 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
C7K40_RS06355 (C7K40_06350)	asnA	1255249..1256241 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
C7K40_RS06360 (C7K40_06355)	arcC	1256554..1257504 (-)	951	WP_002994815.1	carbamate kinase	-
C7K40_RS06365 (C7K40_06360)	-	1257524..1258855 (-)	1332	WP_023612786.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=280454 C7K40_RS06340 WP_002983824.1 1253082..1254119(-) (sepM) [Streptococcus pyogenes strain DMG1800716]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=280454 C7K40_RS06340 WP_002983824.1 1253082..1254119(-) (sepM) [Streptococcus pyogenes strain DMG1800716]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGCAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69