Detailed information NTG0280453

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: C7K40_RS06220
• Genome accession: NZ_CP027771
• Coordinates: 1227380..1229662 (+)
• Length: 760 a.a.
• NCBI ID: WP_023612788.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain DMG1800716
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1222380..1234662

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C7K40_RS06200 (C7K40_06195)	-	1223748..1225157 (-)	1410	WP_023612808.1	deoxyribodipyrimidine photo-lyase	-
C7K40_RS06205 (C7K40_06200)	-	1225306..1226040 (-)	735	WP_023612799.1	amino acid ABC transporter ATP-binding protein	-
C7K40_RS06210 (C7K40_06205)	-	1226040..1226726 (-)	687	WP_114866051.1	amino acid ABC transporter permease	-
C7K40_RS06215 (C7K40_06210)	-	1226853..1227083 (-)	231	WP_002983885.1	YkuJ family protein	-
C7K40_RS06220 (C7K40_06215)	clpE	1227380..1229662 (+)	2283	WP_023612788.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
C7K40_RS06225 (C7K40_06220)	-	1229790..1230245 (+)	456	WP_002989103.1	NUDIX domain-containing protein	-
C7K40_RS06230 (C7K40_06225)	-	1230296..1230598 (+)	303	WP_002983878.1	DUF1827 family protein	-
C7K40_RS06235 (C7K40_06230)	ileS	1230862..1233663 (-)	2802	WP_023612795.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84732.90 Da
• Isoelectric Point: 5.0123

>NTDB_id=280453 C7K40_RS06220 WP_023612788.1 1227380..1229662(+) (clpE) [Streptococcus pyogenes strain DMG1800716]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLLNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide

• Length: 2283 bp

>NTDB_id=280453 C7K40_RS06220 WP_023612788.1 1227380..1229662(+) (clpE) [Streptococcus pyogenes strain DMG1800716]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGCGGTGAATT
GCAGTTGGTCGGCGCTACCACCTTAAATGAATACCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGGATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCTGCTCATTTATCTAATCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCTTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCCTATTCGTTGGACCGACTGGGGTTGGTAAAACAGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAACTAACCGAACAAGTTCGTCGCAATCCTTAT
TCCCTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACGGTCG
CTTAACAGACGGCCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAACATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGACCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.759	98.421	0.834
clpE	Streptococcus pneumoniae Rx1	82.69	98.816	0.817
clpE	Streptococcus pneumoniae D39	82.69	98.816	0.817
clpE	Streptococcus pneumoniae R6	82.69	98.816	0.817
clpE	Streptococcus pneumoniae TIGR4	82.557	98.816	0.816
clpC	Lactococcus lactis subsp. cremoris KW2	75.164	100	0.753
clpC	Bacillus subtilis subsp. subtilis str. 168	51.745	86.711	0.449
clpC	Streptococcus pneumoniae D39	48	82.237	0.395
clpC	Streptococcus pneumoniae Rx1	48	82.237	0.395
clpC	Streptococcus pneumoniae TIGR4	48	82.237	0.395
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46	85.526	0.393
clpC	Streptococcus mutans UA159	47.735	81.316	0.388
clpC	Streptococcus thermophilus LMD-9	47.276	82.105	0.388
clpC	Streptococcus thermophilus LMG 18311	46.955	82.105	0.386