Detailed information NTG0027865

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: SPYM_RS05690
• Genome accession: NC_009332
• Coordinates: 1116259..1117488 (-)
• Length: 409 a.a.
• NCBI ID: WP_011888976.1
• Uniprot ID: A2RF17
• Organism: Streptococcus pyogenes str. Manfredo
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1111259..1122488

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM_RS05670 (SpyM51113)	rpiA	1111541..1112224 (-)	684	WP_009881270.1	ribose-5-phosphate isomerase RpiA	-
SPYM_RS05675 (SpyM51114)	-	1112602..1114701 (+)	2100	WP_002984939.1	AAA family ATPase	-
SPYM_RS05680 (SpyM51115)	-	1114759..1115502 (-)	744	WP_002984942.1	hypothetical protein	-
SPYM_RS05685 (SpyM51116)	yihA	1115650..1116249 (-)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
SPYM_RS05690 (SpyM51117)	clpX	1116259..1117488 (-)	1230	WP_011888976.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
SPYM_RS09845 (SpyM51118)	-	1117618..1117788 (-)	171	WP_002990165.1	hypothetical protein	-
SPYM_RS05700 (SpyM51119)	-	1117808..1118305 (-)	498	WP_011184412.1	dihydrofolate reductase	-
SPYM_RS05705 (SpyM51120)	-	1118385..1119224 (-)	840	WP_011017679.1	thymidylate synthase	-
SPYM_RS05710 (SpyM51121)	-	1119433..1120608 (+)	1176	WP_011888977.1	hydroxymethylglutaryl-CoA synthase	-
SPYM_RS05715 (SpyM51122)	-	1120595..1121872 (+)	1278	WP_002984963.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45006.50 Da
• Isoelectric Point: 4.6184

>NTDB_id=27865 SPYM_RS05690 WP_011888976.1 1116259..1117488(-) (clpX) [Streptococcus pyogenes str. Manfredo]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=27865 SPYM_RS05690 WP_011888976.1 1116259..1117488(-) (clpX) [Streptococcus pyogenes str. Manfredo]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

3D structure

• AlphaFold DB: A2RF17

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.853	98.044	0.577