Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   SPYM_RS03140 Genome accession   NC_009332
Coordinates   610577..611614 (+) Length   345 a.a.
NCBI ID   WP_010922499.1    Uniprot ID   A0A4U9I5V9
Organism   Streptococcus pyogenes str. Manfredo     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 605577..616614
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYM_RS03115 (SpyM50581) - 605841..607172 (+) 1332 WP_011888730.1 dipeptidase -
  SPYM_RS03120 (SpyM50582) arcC 607192..608142 (+) 951 WP_011528820.1 carbamate kinase -
  SPYM_RS03125 (SpyM50584) asnA 608455..609447 (+) 993 WP_011888731.1 aspartate--ammonia ligase -
  SPYM_RS03130 (SpyM50585) rsmD 609570..610109 (+) 540 WP_011888732.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  SPYM_RS03135 (SpyM50586) coaD 610099..610590 (+) 492 WP_002983821.1 pantetheine-phosphate adenylyltransferase -
  SPYM_RS03140 (SpyM50587) sepM 610577..611614 (+) 1038 WP_010922499.1 SepM family pheromone-processing serine protease Regulator
  SPYM_RS03145 (SpyM50588) - 612026..613003 (+) 978 WP_002989070.1 LacI family DNA-binding transcriptional regulator -
  SPYM_RS03150 (SpyM50590) - 613451..614071 (+) 621 WP_002992791.1 YutD family protein -
  SPYM_RS03155 (SpyM50591) rlmN 614075..615154 (+) 1080 WP_011184761.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  SPYM_RS03160 (SpyM50592) - 615236..615862 (-) 627 WP_011888733.1 prepilin peptidase -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37541.24 Da        Isoelectric Point: 9.6692

>NTDB_id=27857 SPYM_RS03140 WP_010922499.1 610577..611614(+) (sepM) [Streptococcus pyogenes str. Manfredo]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=27857 SPYM_RS03140 WP_010922499.1 610577..611614(+) (sepM) [Streptococcus pyogenes str. Manfredo]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9I5V9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

69.275

100

0.693

Multiple sequence alignment