Detailed information NTG0277950

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPV_RS09395
• Genome accession: NZ_CP027540
• Coordinates: 1764504..1765541 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain D39V
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1759504..1770541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPV_RS09370 (SPV_1761)	-	1760305..1761636 (-)	1332	WP_000390046.1	hemolysin family protein	-
SPV_RS09375 (SPV_1762)	endA	1761865..1762689 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
SPV_RS09380 (SPV_1763)	-	1762728..1762916 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SPV_RS09385 (SPV_1764)	murA	1762909..1764192 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPV_RS09390 (SPV_2422)	-	1764216..1764446 (-)	231	WP_000250384.1	DUF1146 family protein	-
SPV_RS09395 (SPV_1765)	sepM	1764504..1765541 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SPV_RS09400 (SPV_1766)	coaD	1765525..1766013 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
SPV_RS09405 (SPV_1767)	rsmD	1766003..1766542 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPV_RS09410 (SPV_1768)	asnA	1766607..1767599 (-)	993	WP_000747995.1	aspartate--ammonia ligase	-
SPV_RS09420 (SPV_1769)	-	1767711..1768394 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SPV_RS09425 (SPV_1771)	-	1768450..1769190 (-)	741	WP_000152673.1	RNA methyltransferase	-
SPV_RS09430 (SPV_1772)	-	1769224..1769502 (+)	279	WP_001174613.1	acylphosphatase	-
SPV_RS09435 (SPV_1773)	yidC	1769580..1770506 (+)	927	WP_000835947.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=277950 SPV_RS09395 WP_000727277.1 1764504..1765541(-) (sepM) [Streptococcus pneumoniae strain D39V]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=277950 SPV_RS09395 WP_000727277.1 1764504..1765541(-) (sepM) [Streptococcus pneumoniae strain D39V]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591