Detailed information NTG0277904

Bioinformatically predicted

Overview

• Name: comB
• Type: Regulator
• Locus tag: SPV_RS00240
• Genome accession: NZ_CP027540
• Coordinates: 44068..45417 (+)
• Length: 449 a.a.
• NCBI ID: WP_000801613.1
• Uniprot ID: A0A2U3RX82
• Organism: Streptococcus pneumoniae strain D39V
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 39068..50417

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPV_RS00220 (SPV_0046)	blpU	39514..39744 (+)	231	WP_001093075.1	bacteriocin-like peptide BlpU	-
SPV_RS11870 (SPV_0047)	-	39747..39872 (+)	126	WP_000346297.1	PncF family bacteriocin immunity protein	-
SPV_RS00235 (SPV_0049)	comA	41902..44055 (+)	2154	WP_000668290.1	peptide cleavage/export ABC transporter ComA	Regulator
SPV_RS00240 (SPV_0050)	comB	44068..45417 (+)	1350	WP_000801613.1	competence pheromone export protein ComB	Regulator
SPV_RS00245 (SPV_0051)	purC	45587..46294 (+)	708	WP_000043299.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SPV_RS11990	-	46296..46439 (+)	144	WP_050167432.1	hypothetical protein	-
SPV_RS00255 (SPV_0052)	-	46496..50221 (+)	3726	WP_000361172.1	phosphoribosylformylglycinamidine synthase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 49613.45 Da
• Isoelectric Point: 5.3895

>NTDB_id=277904 SPV_RS00240 WP_000801613.1 44068..45417(+) (comB) [Streptococcus pneumoniae strain D39V]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGTSLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELSLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGTLLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide

• Length: 1350 bp

>NTDB_id=277904 SPV_RS00240 WP_000801613.1 44068..45417(+) (comB) [Streptococcus pneumoniae strain D39V]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCCAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTACTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGAGCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTACCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCTTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTAGATCAATTTTTGAACAAAGAGTAA

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A2U3RX82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comB	Streptococcus pneumoniae Rx1	100	100	1
comB	Streptococcus pneumoniae D39	100	100	1
comB	Streptococcus pneumoniae R6	100	100	1
comB	Streptococcus pneumoniae TIGR4	98.886	100	0.989
comB	Streptococcus mitis SK321	94.878	100	0.949
comB	Streptococcus mitis NCTC 12261	93.987	100	0.94
comB	Streptococcus gordonii str. Challis substr. CH1	55.556	100	0.557