Detailed information NTG0027490

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LLMG_RS12255
• Genome accession: NC_009004
• Coordinates: 2393837..2394868 (-)
• Length: 343 a.a.
• NCBI ID: WP_011836077.1
• Uniprot ID: A0A084AC41
• Organism: Lactococcus cremoris subsp. cremoris MG1363
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2388837..2399868

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLMG_RS14015	-	2388946..2389872 (-)	927	WP_228764267.1	radical SAM protein	-
LLMG_RS12240 (llmg_2438)	-	2389975..2390832 (-)	858	WP_011836073.1	Rgg/GadR/MutR family transcriptional regulator	-
LLMG_RS12245 (llmg_2439)	-	2390884..2391933 (-)	1050	WP_228764266.1	MFS transporter	-
LLMG_RS12250 (llmg_2440)	kwcM	2392017..2393336 (-)	1320	WP_011836075.1	KxxxW cyclic peptide radical SAM maturase	-
LLMG_RS13325 (llmg_2441)	-	2393404..2393517 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
LLMG_RS12255 (llmg_2442)	sepM	2393837..2394868 (-)	1032	WP_011836077.1	SepM family pheromone-processing serine protease	Regulator
LLMG_RS12260 (llmg_2443)	coaD	2394852..2395352 (-)	501	WP_011836078.1	pantetheine-phosphate adenylyltransferase	-
LLMG_RS12265 (llmg_2444)	rsmD	2395400..2395939 (-)	540	WP_011836079.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LLMG_RS12270 (llmg_2445)	-	2396112..2397329 (-)	1218	WP_011836080.1	MDR family MFS transporter	-
LLMG_RS12275 (llmg_2446)	lmrP	2397414..2398640 (-)	1227	WP_011836081.1	multidrug efflux MFS transporter LmrP	-
LLMG_RS12280 (llmg_pseudo_76)	-	2398875..2399318 (+)	444	WP_041931231.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37403.02 Da
• Isoelectric Point: 9.9119

>NTDB_id=27490 LLMG_RS12255 WP_011836077.1 2393837..2394868(-) (sepM) [Lactococcus cremoris subsp. cremoris MG1363]
MNKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKISNGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGMMFTLEIYSQLTGKNLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALTYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=27490 LLMG_RS12255 WP_011836077.1 2393837..2394868(-) (sepM) [Lactococcus cremoris subsp. cremoris MG1363]
ATGAACAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGCCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGGAAAATGGTCAAAGTTGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGTGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGTCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACTGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGCAGTAAACACAAGTCTACTGGAAAATATATCAAAATCTCTAATGGAAAAACCGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATGATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAAATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAACTTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A084AC41

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.406	100	0.487