Detailed information NTG0274006

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RK61_RS08220
• Genome accession: NZ_CP026964
• Coordinates: 1594670..1595713 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1589670..1600713

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RK61_RS08180 (RK61_08180)	-	1590036..1590147 (+)	112	Protein_1527	hypothetical protein	-
RK61_RS08185 (RK61_08185)	-	1590176..1590589 (+)	414	WP_001837236.1	hypothetical protein	-
RK61_RS08195 (RK61_08195)	-	1591079..1592065 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
RK61_RS08205 (RK61_08205)	map	1592596..1593354 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RK61_RS08210 (RK61_08210)	-	1593571..1593957 (+)	387	WP_001110179.1	hypothetical protein	-
RK61_RS08215 (RK61_08215)	liaF	1593972..1594673 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RK61_RS08220 (RK61_08220)	vraS	1594670..1595713 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RK61_RS08225 (RK61_08225)	vraR	1595703..1596332 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RK61_RS08230 (RK61_08230)	-	1596444..1597655 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
RK61_RS08235 (RK61_08235)	-	1597933..1598208 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RK61_RS08240 (RK61_08240)	-	1598215..1598679 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RK61_RS08245 (RK61_08245)	-	1598826..1599026 (+)	201	WP_000180460.1	DUF1128 family protein	-
RK61_RS08250 (RK61_08250)	-	1599029..1600285 (+)	1257	WP_078055712.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=274006 RK61_RS08220 WP_001017131.1 1594670..1595713(+) (vraS) [Staphylococcus aureus strain FDAARGOS_2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=274006 RK61_RS08220 WP_001017131.1 1594670..1595713(+) (vraS) [Staphylococcus aureus strain FDAARGOS_2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1