Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   C4N11_RS10265 Genome accession   NZ_CP026670
Coordinates   1929844..1930668 (-) Length   274 a.a.
NCBI ID   WP_001036779.1    Uniprot ID   P0A3S3
Organism   Streptococcus pneumoniae strain endophthalmitis isolate 335     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Genomic Context

Location: 1924844..1935668
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C4N11_RS10260 (C4N11_10260) - 1928284..1929615 (-) 1332 WP_000390046.1 hemolysin family protein -
  C4N11_RS10265 (C4N11_10265) endA 1929844..1930668 (-) 825 WP_001036779.1 DNA-entry nuclease EndA Machinery gene
  C4N11_RS10270 (C4N11_10270) - 1930707..1930895 (-) 189 WP_001036519.1 DNA-directed RNA polymerase subunit beta -
  C4N11_RS10275 (C4N11_10275) murA 1930888..1932171 (-) 1284 WP_000358033.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  C4N11_RS10280 (C4N11_10280) - 1932195..1932425 (-) 231 WP_000615437.1 DUF1146 family protein -
  C4N11_RS10285 (C4N11_10285) sepM 1932483..1933520 (-) 1038 WP_000727280.1 SepM family pheromone-processing serine protease Regulator
  C4N11_RS10290 (C4N11_10290) coaD 1933504..1933992 (-) 489 WP_001280766.1 pantetheine-phosphate adenylyltransferase -
  C4N11_RS10295 (C4N11_10295) rsmD 1933982..1934521 (-) 540 WP_000706960.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  C4N11_RS10300 (C4N11_10300) asnA 1934586..1935578 (-) 993 WP_000747993.1 aspartate--ammonia ligase -

Sequence

Protein


Download         Length: 274 a.a.        Molecular weight: 29890.57 Da        Isoelectric Point: 10.1197

>NTDB_id=271457 C4N11_RS10265 WP_001036779.1 1929844..1930668(-) (endA) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MNKKTRQTLIGLLVLLLLSTGSYYIKQMPSAPNSPKTNLSQKKQASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIV
NGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDLVPSASQIE
AKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ

Nucleotide


Download         Length: 825 bp        

>NTDB_id=271457 C4N11_RS10265 WP_001036779.1 1929844..1930668(-) (endA) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGAACAAAAAAACAAGACAGACACTAATCGGACTGCTAGTGTTATTGCTTTTGTCTACAGGGAGCTATTATATCAAGCA
GATGCCGTCGGCACCTAATAGTCCCAAAACCAATCTTAGTCAGAAAAAACAAGCGTCTGAAGCTCCTAGTCAAGCATTGG
CAGAGAGTGTCTTAACAGACGCAGTCAAGAGTCAAATAAAGGGGAGTCTGGAGTGGAATGGCTCAGGTGCTTTTATCGTC
AATGGTAATAAAACAAATCTAGATGCCAAGGTTTCAAGTAAGCCCTACGCTGACAATAAAACAAAGACAGTGGGCAAGGA
AACTGTTCCAACCGTAGCTAATGCCCTCTTGTCTAAGGCCACTCGTCAGTACAAGAATCGTAAAGAAACTGGGAATGGTT
CAACTTCTTGGACTCCTCCAGGTTGGCATCAGGTCAAGAATCTAAAGGGCTCTTATACCCATGCAGTCGATAGAGGTCAT
TTGTTAGGCTATGCCTTAATCGGTGGTTTGGATGGTTTTGATGCCTCAACAAGCAATCCTAAAAACATTGCTGTTCAGAC
AGCCTGGGCAAATCAGGCACAAGCCGAGTATTCGACTGGTCAAAACTACTATGAAAGCAAGGTGCGTAAAGCCTTGGACC
AAAACAAGCGTGTCCGTTACCGTGTAACCCTTTACTACGCTTCAAACGAGGATTTAGTTCCCTCAGCTTCACAGATTGAA
GCCAAGTCTTCGGATGGAGAATTGGAATTCAATGTTCTAGTTCCCAATGTTCAAAAGGGACTTCAACTGGATTACCGAAC
TGGAGAAGTAACTGTAACTCAGTAA

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(75-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 3OWV

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

100

100

1
  endA Streptococcus pneumoniae D39

100

100

1
  endA Streptococcus pneumoniae R6

100

100

1
  endA Streptococcus pneumoniae TIGR4

100

100

1

Multiple sequence alignment