Detailed information NTG0266834

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RK70_RS00590
• Genome accession: NZ_CP026080
• Coordinates: 110631..111674 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_12
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 105631..116674

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RK70_RS00545 (RK70_000545)	-	106060..106170 (+)	111	WP_001790257.1	hypothetical protein	-
RK70_RS00550 (RK70_000550)	-	106199..106612 (+)	414	WP_001549145.1	hypothetical protein	-
RK70_RS00560 (RK70_000560)	-	107043..108029 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
RK70_RS00575 (RK70_000575)	map	108557..109315 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RK70_RS00580 (RK70_000580)	-	109532..109918 (+)	387	WP_001110179.1	hypothetical protein	-
RK70_RS00585 (RK70_000585)	liaF	109933..110634 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RK70_RS00590 (RK70_000590)	vraS	110631..111674 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RK70_RS00595 (RK70_000595)	vraR	111664..112293 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
RK70_RS00600 (RK70_000600)	-	112409..113626 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RK70_RS00605 (RK70_000605)	-	113904..114179 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RK70_RS00610 (RK70_000610)	-	114186..114650 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RK70_RS00615 (RK70_000615)	-	114797..114997 (+)	201	WP_000180461.1	DUF1128 family protein	-
RK70_RS00620 (RK70_000620)	-	115000..116256 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=266834 RK70_RS00590 WP_001017131.1 110631..111674(+) (vraS) [Staphylococcus aureus strain FDAARGOS_12]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=266834 RK70_RS00590 WP_001017131.1 110631..111674(+) (vraS) [Staphylococcus aureus strain FDAARGOS_12]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1