Detailed information NTG0266606

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RK93_RS13125
• Genome accession: NZ_CP026072
• Coordinates: 2494504..2495547 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_35
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2489504..2500547

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RK93_RS13085 (RK93_013085)	-	2489815..2489925 (+)	111	WP_001790257.1	hypothetical protein	-
RK93_RS13090 (RK93_013090)	-	2489954..2490367 (+)	414	WP_001549145.1	hypothetical protein	-
RK93_RS13100 (RK93_013100)	-	2490857..2491843 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
RK93_RS13110 (RK93_013110)	map	2492430..2493188 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RK93_RS13115 (RK93_013115)	-	2493405..2493791 (+)	387	WP_001110181.1	hypothetical protein	-
RK93_RS13120 (RK93_013120)	liaF	2493806..2494507 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RK93_RS13125 (RK93_013125)	vraS	2494504..2495547 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RK93_RS13130 (RK93_013130)	vraR	2495537..2496166 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
RK93_RS13135 (RK93_013135)	-	2496282..2497499 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RK93_RS13140 (RK93_013140)	-	2497777..2498052 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RK93_RS13145 (RK93_013145)	-	2498059..2498523 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RK93_RS13150 (RK93_013150)	-	2498670..2498870 (+)	201	WP_000180461.1	DUF1128 family protein	-
RK93_RS13155 (RK93_013155)	-	2498873..2500129 (+)	1257	WP_001797521.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=266606 RK93_RS13125 WP_001017131.1 2494504..2495547(+) (vraS) [Staphylococcus aureus strain FDAARGOS_35]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=266606 RK93_RS13125 WP_001017131.1 2494504..2495547(+) (vraS) [Staphylococcus aureus strain FDAARGOS_35]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1