Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | RK93_RS08215 | Genome accession | NZ_CP026072 |
| Coordinates | 1596199..1597827 (+) | Length | 542 a.a. |
| NCBI ID | WP_001186608.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain FDAARGOS_35 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1566593..1621094 | 1596199..1597827 | within | 0 |
| SCCmec | 1587431..1604591 | 1596199..1597827 | within | 0 |
Gene organization within MGE regions
Location: 1566593..1621094
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RK93_RS08055 (RK93_008055) | - | 1566875..1567425 (+) | 551 | Protein_1519 | flavodoxin family protein | - |
| RK93_RS08060 (RK93_008060) | - | 1567418..1568638 (+) | 1221 | WP_000130764.1 | MFS transporter | - |
| RK93_RS08065 (RK93_008065) | - | 1568710..1569006 (-) | 297 | WP_000201640.1 | TfoX/Sxy family protein | - |
| RK93_RS08070 (RK93_008070) | - | 1569055..1569258 (-) | 204 | WP_000398679.1 | DUF6007 family protein | - |
| RK93_RS08075 (RK93_008075) | - | 1569567..1570553 (+) | 987 | WP_000662031.1 | tRNA-dihydrouridine synthase | - |
| RK93_RS16070 | - | 1570739..1570953 (+) | 215 | Protein_1524 | universal stress protein | - |
| RK93_RS08090 (RK93_008090) | sqr | 1571220..1571786 (-) | 567 | Protein_1525 | type II sulfide:quinone oxidoreductase Sqr | - |
| RK93_RS08095 (RK93_008095) | - | 1571873..1572688 (-) | 816 | WP_000160701.1 | AAA family ATPase | - |
| RK93_RS08100 (RK93_008100) | - | 1572681..1574123 (-) | 1443 | WP_000790709.1 | Mu transposase C-terminal domain-containing protein | - |
| RK93_RS08105 (RK93_008105) | - | 1574095..1574688 (-) | 594 | WP_000690636.1 | recombinase family protein | - |
| RK93_RS08110 (RK93_008110) | blaI | 1574952..1575332 (-) | 381 | WP_001284656.1 | penicillinase repressor BlaI | - |
| RK93_RS08115 (RK93_008115) | blaR1 | 1575322..1577079 (-) | 1758 | WP_001096374.1 | beta-lactam sensor/signal transducer BlaR1 | - |
| RK93_RS08120 (RK93_008120) | - | 1577186..1578031 (+) | 846 | WP_000733283.1 | BlaZ family penicillin-hydrolyzing class A beta-lactamase PC1 | - |
| RK93_RS08130 (RK93_008130) | sqr | 1578333..1578965 (-) | 633 | Protein_1532 | type II sulfide:quinone oxidoreductase Sqr | - |
| RK93_RS08135 (RK93_008135) | cstB | 1578984..1580318 (-) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| RK93_RS08140 (RK93_008140) | cstA | 1580349..1581416 (-) | 1068 | WP_000816129.1 | persulfide response sulfurtransferase CstA | - |
| RK93_RS08145 (RK93_008145) | cstR | 1581553..1581813 (+) | 261 | WP_001105087.1 | persulfide-sensing transcriptional repressor CstR | - |
| RK93_RS08150 (RK93_008150) | - | 1581813..1582568 (+) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| RK93_RS08155 (RK93_008155) | - | 1582666..1582767 (+) | 102 | WP_001791873.1 | hypothetical protein | - |
| RK93_RS08160 (RK93_008160) | - | 1582783..1583235 (+) | 453 | Protein_1538 | tRNA-dihydrouridine synthase | - |
| RK93_RS08165 (RK93_008165) | - | 1583329..1585076 (-) | 1748 | Protein_1539 | DUF6119 family protein | - |
| RK93_RS08170 (RK93_008170) | - | 1585223..1585315 (-) | 93 | WP_001790000.1 | hypothetical protein | - |
| RK93_RS08175 (RK93_008175) | - | 1585279..1585413 (+) | 135 | WP_001790628.1 | hypothetical protein | - |
| RK93_RS08180 (RK93_008180) | - | 1585807..1587438 (-) | 1632 | WP_001036765.1 | hypothetical protein | - |
| RK93_RS08185 (RK93_008185) | - | 1587431..1589302 (-) | 1872 | WP_000666921.1 | zinc-ribbon domain-containing protein | - |
| RK93_RS15840 | - | 1589604..1589753 (-) | 150 | WP_000369743.1 | hypothetical protein | - |
| RK93_RS08190 (RK93_008190) | - | 1589753..1591267 (-) | 1515 | WP_000627204.1 | protein kinase | - |
| RK93_RS08195 (RK93_008195) | - | 1591285..1592352 (-) | 1068 | WP_001099283.1 | hypothetical protein | - |
| RK93_RS08200 (RK93_008200) | - | 1592508..1592801 (+) | 294 | WP_000182688.1 | single-stranded DNA-binding protein | - |
| RK93_RS08205 (RK93_008205) | - | 1592801..1594594 (+) | 1794 | WP_000195099.1 | DUF927 domain-containing protein | - |
| RK93_RS08210 (RK93_008210) | ccrA | 1594828..1596177 (+) | 1350 | WP_000815638.1 | recombinase family protein | Machinery gene |
| RK93_RS08215 (RK93_008215) | ccrB | 1596199..1597827 (+) | 1629 | WP_001186608.1 | recombinase family protein | Machinery gene |
| RK93_RS08220 (RK93_008220) | - | 1598349..1598699 (+) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| RK93_RS08230 (RK93_008230) | - | 1598786..1599097 (+) | 312 | WP_000700851.1 | DUF960 family protein | - |
| RK93_RS08235 (RK93_008235) | - | 1599112..1599618 (+) | 507 | WP_001092188.1 | DUF1643 domain-containing protein | - |
| RK93_RS08240 (RK93_008240) | - | 1599670..1601277 (+) | 1608 | Protein_1554 | IS1182 family transposase | - |
| RK93_RS08245 (RK93_008245) | - | 1601300..1601575 (-) | 276 | Protein_1555 | type I restriction enzyme endonuclease domain-containing protein | - |
| RK93_RS08250 (RK93_008250) | - | 1601499..1602485 (-) | 987 | WP_001549960.1 | beta-lactam sensor/signal transducer MecR1 | - |
| RK93_RS08255 (RK93_008255) | mecA | 1602582..1604591 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| RK93_RS08260 (RK93_008260) | - | 1604637..1605065 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| RK93_RS08265 (RK93_008265) | - | 1605162..1605905 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| RK93_RS08270 (RK93_008270) | - | 1606170..1606844 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| RK93_RS08275 (RK93_008275) | aadD1 | 1607037..1607807 (+) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| RK93_RS08280 (RK93_008280) | bleO | 1608024..1608428 (+) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| RK93_RS08285 (RK93_008285) | mobV | 1608935..1610197 (+) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| RK93_RS08290 (RK93_008290) | - | 1610442..1611425 (+) | 984 | Protein_1564 | protein rep | - |
| RK93_RS08300 (RK93_008300) | - | 1611516..1612190 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| RK93_RS08305 (RK93_008305) | - | 1612222..1612461 (-) | 240 | WP_001282728.1 | hypothetical protein | - |
| RK93_RS08310 (RK93_008310) | - | 1612876..1614132 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| RK93_RS08315 (RK93_008315) | rlmH | 1614454..1614933 (-) | 480 | WP_000704775.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| RK93_RS08320 (RK93_008320) | adsA | 1615301..1617623 (-) | 2323 | Protein_1569 | LPXTG-anchored adenosine synthase AdsA | - |
| RK93_RS08330 (RK93_008330) | - | 1617851..1618651 (-) | 801 | WP_000088648.1 | MBL fold metallo-hydrolase | - |
| RK93_RS08335 (RK93_008335) | yycI | 1619041..1619829 (-) | 789 | WP_001104172.1 | two-component system regulatory protein YycI | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62654.83 Da Isoelectric Point: 9.7970
>NTDB_id=266597 RK93_RS08215 WP_001186608.1 1596199..1597827(+) (ccrB) [Staphylococcus aureus strain FDAARGOS_35]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=266597 RK93_RS08215 WP_001186608.1 1596199..1597827(+) (ccrB) [Staphylococcus aureus strain FDAARGOS_35]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACTCTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAACACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACTCTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAACACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
98.893 |
100 |
0.989 |