Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LEUM_RS09475 Genome accession   NC_008531
Coordinates   1918134..1919273 (-) Length   379 a.a.
NCBI ID   WP_011680488.1    Uniprot ID   Q03UV5
Organism   Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1913134..1924273
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LEUM_RS09455 (LEUM_1942) - 1913509..1914174 (+) 666 WP_010285559.1 NAD(P)H-hydrate epimerase -
  LEUM_RS09460 (LEUM_1943) - 1914259..1914711 (-) 453 WP_011680485.1 Rrf2 family transcriptional regulator -
  LEUM_RS09465 (LEUM_1944) - 1914765..1916930 (-) 2166 WP_011680486.1 YhgE/Pip domain-containing protein -
  LEUM_RS09470 (LEUM_1945) rlmH 1917024..1917503 (-) 480 WP_011680487.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LEUM_RS09475 (LEUM_1946) htrA 1918134..1919273 (-) 1140 WP_011680488.1 S1C family serine protease Regulator
  LEUM_RS09480 (LEUM_1947) yycI 1919334..1920137 (-) 804 WP_010289058.1 two-component system regulatory protein YycI -
  LEUM_RS09485 (LEUM_1948) - 1920194..1921486 (-) 1293 WP_011680489.1 hypothetical protein -
  LEUM_RS09490 (LEUM_1949) walK 1921476..1923341 (-) 1866 WP_041775298.1 cell wall metabolism sensor histidine kinase WalK -
  LEUM_RS09495 (LEUM_1950) yycF 1923409..1924116 (-) 708 WP_010281559.1 response regulator YycF -

Sequence

Protein


Download         Length: 379 a.a.        Molecular weight: 39220.52 Da        Isoelectric Point: 9.7777

>NTDB_id=26643 LEUM_RS09475 WP_011680488.1 1918134..1919273(-) (htrA) [Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293]
MVQPALTKTLLTGVIAGVVGGGAILYGQQGVQLLQNQNQKVSTTATSTKTIAKNATATSAYNKVSDAVVSVLNFTKSSQG
SYQESSEGSGVIYKKTDGSAFIVTNNHVITGAAKIQVMLHSGKKVTATLVGKDAMTDLAVLKIDGTDVTTTAQFGDSSKI
TVGENVLAIGSPLGSEYASSVTQGIISAKKRLVEATSENGQNYGGSTVIQTDAAINPGNSGGPLINFAGQVIGINSMKLS
TSSSGTSVEGMGFAIPSDQVVDIVNKLVKDGKVTRPAIGISLINLSEVTASEQKSTLKIPDSVTGGVVVMSLTNNGPADK
AGLKKYDVIVGINGKKVSSQADLREELYKHSLGDTITLTYYHQDTKQTVKVKLTQKLAS

Nucleotide


Download         Length: 1140 bp        

>NTDB_id=26643 LEUM_RS09475 WP_011680488.1 1918134..1919273(-) (htrA) [Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293]
ATGGTACAACCAGCATTAACAAAAACGTTGTTAACTGGCGTCATTGCTGGTGTTGTTGGTGGAGGAGCAATTTTGTATGG
GCAGCAGGGTGTACAATTGTTACAAAATCAAAATCAAAAAGTGAGTACGACAGCAACAAGTACAAAAACGATTGCCAAGA
ATGCAACTGCTACATCAGCTTATAATAAGGTATCAGATGCAGTTGTATCTGTATTGAACTTTACTAAATCCAGTCAAGGT
AGTTATCAAGAATCGTCAGAAGGTTCTGGCGTGATCTATAAAAAAACGGATGGATCGGCATTTATTGTAACGAATAATCA
CGTAATCACTGGAGCGGCTAAAATTCAAGTTATGCTGCACAGTGGGAAGAAAGTGACCGCTACATTAGTCGGCAAAGATG
CGATGACTGACTTAGCTGTTCTGAAAATCGACGGCACAGACGTTACAACAACTGCACAATTTGGCGATTCAAGTAAAATA
ACTGTTGGTGAAAACGTCTTGGCAATTGGTTCGCCGCTGGGATCTGAGTATGCTTCGTCAGTGACGCAAGGCATCATTTC
GGCCAAGAAAAGGTTAGTTGAGGCAACATCTGAAAATGGTCAAAATTATGGTGGATCCACGGTTATTCAGACGGATGCTG
CTATTAATCCTGGTAACTCAGGTGGACCATTAATCAACTTTGCAGGACAAGTTATTGGTATTAACTCAATGAAGTTATCA
ACATCTTCTTCTGGAACGAGCGTTGAGGGGATGGGTTTTGCAATTCCTTCTGATCAAGTCGTTGACATTGTTAACAAATT
AGTCAAAGATGGTAAAGTCACACGACCAGCAATTGGCATTAGTTTGATTAATTTGTCAGAAGTAACAGCTTCTGAGCAAA
AATCAACATTGAAAATTCCAGATAGCGTTACTGGTGGTGTTGTTGTAATGAGTTTGACTAACAATGGCCCAGCAGATAAA
GCTGGATTGAAGAAGTACGACGTTATTGTTGGCATTAATGGTAAAAAGGTCAGCTCACAGGCTGATCTGCGAGAAGAACT
CTACAAGCATTCGCTTGGGGACACAATAACATTGACTTATTATCATCAGGATACTAAGCAAACCGTCAAGGTTAAATTAA
CACAGAAATTAGCAAGCTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(276-373)

Peptidase family M50 (Peptidase_M50)

(221-375)

Trypsin-like peptidase domain (Trypsin_2)

(88-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03UV5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

52.394

93.668

0.491
  htrA Streptococcus gordonii str. Challis substr. CH1

48.549

100

0.485
  htrA Streptococcus pneumoniae D39

52.924

90.237

0.478
  htrA Streptococcus pneumoniae TIGR4

52.924

90.237

0.478
  htrA Streptococcus pneumoniae R6

52.924

90.237

0.478
  htrA Streptococcus pneumoniae Rx1

52.924

90.237

0.478
  htrA Streptococcus mutans UA159

52.647

89.71

0.472

Multiple sequence alignment