Detailed information NTG0266369

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RK78_RS13150
• Genome accession: NZ_CP026066
• Coordinates: 2582287..2583330 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_20
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2577287..2588330

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RK78_RS13120 (RK78_013120)	-	2577708..2578964 (-)	1257	WP_001793983.1	aminopeptidase	-
RK78_RS13125 (RK78_013125)	-	2578967..2579167 (-)	201	WP_000180460.1	DUF1128 family protein	-
RK78_RS13130 (RK78_013130)	-	2579314..2579778 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
RK78_RS13135 (RK78_013135)	-	2579785..2580060 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RK78_RS13140 (RK78_013140)	-	2580338..2581555 (+)	1218	WP_000037082.1	YihY/virulence factor BrkB family protein	-
RK78_RS13145 (RK78_013145)	vraR	2581668..2582297 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RK78_RS13150 (RK78_013150)	vraS	2582287..2583330 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RK78_RS13155 (RK78_013155)	liaF	2583327..2584028 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RK78_RS13160 (RK78_013160)	-	2584043..2584429 (-)	387	WP_001110178.1	hypothetical protein	-
RK78_RS13165 (RK78_013165)	map	2584646..2585404 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RK78_RS13175 (RK78_013175)	-	2585985..2586971 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
RK78_RS13180 (RK78_013180)	-	2587160..2587573 (-)	414	WP_001643743.1	hypothetical protein	-
RK78_RS13185 (RK78_013185)	-	2587602..2587712 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=266369 RK78_RS13150 WP_001017131.1 2582287..2583330(-) (vraS) [Staphylococcus aureus strain FDAARGOS_20]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=266369 RK78_RS13150 WP_001017131.1 2582287..2583330(-) (vraS) [Staphylococcus aureus strain FDAARGOS_20]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1