Detailed information NTG0266331

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DY328_RS02445
• Genome accession: NZ_CP031556
• Coordinates: 458083..458757 (-)
• Length: 224 a.a.
• NCBI ID: WP_001238594.1
• Uniprot ID: P0A4I0
• Organism: Streptococcus agalactiae strain Sag27
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 453083..463757

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DY328_RS02420 (DY328_02420)	dltC	453699..453938 (-)	240	WP_000351975.1	D-alanine--poly(phosphoribitol) ligase subunit DltC	-
DY328_RS02425 (DY328_02425)	dltB	453953..455218 (-)	1266	WP_000613595.1	D-alanyl-lipoteichoic acid biosynthesis protein DltB	-
DY328_RS02430 (DY328_02430)	dltA	455215..456750 (-)	1536	WP_000581010.1	D-alanine--poly(phosphoribitol) ligase subunit DltA	-
DY328_RS02435 (DY328_02435)	dltX	456763..456885 (-)	123	WP_000806142.1	teichoic acid D-Ala incorporation-associated protein DltX	-
DY328_RS02440 (DY328_02440)	dltS	456896..458083 (-)	1188	WP_000490535.1	two-component system sensor histidine kinase DltS	-
DY328_RS02445 (DY328_02445)	ciaR	458083..458757 (-)	675	WP_001238594.1	two-component system response regulator DltR	Regulator
DY328_RS02450 (DY328_02450)	rpmH	459113..459247 (-)	135	WP_000831903.1	50S ribosomal protein L34	-
DY328_RS02460 (DY328_02460)	-	459456..460589 (-)	1134	WP_000564846.1	ISAs1-like element IS1548 family transposase	-
DY328_RS02465 (DY328_02465)	-	460756..462111 (-)	1356	WP_000712231.1	YjiH family protein	-
DY328_RS02470 (DY328_02470)	-	462343..463509 (+)	1167	WP_000160532.1	IS30-like element ISSag9 family transposase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25504.44 Da
• Isoelectric Point: 5.4971

>NTDB_id=266331 DY328_RS02445 WP_001238594.1 458083..458757(-) (ciaR) [Streptococcus agalactiae strain Sag27]
MRLLVVEDEKSIAEAIQALLADKGYSVDLAFDGDDGLEYILTGLYDLVLLDIMLPKRSGLSVLKRVREAGLETPIIFLTA
KSQTYDKVNGLDLGADDYITKPFEADELLARIRLRTRQSSLIRANQLRLGNIRLNTDSHELESKESSVKLSNKEFLLMEV
FMRNAKQIIPKNQLISKVWGPSDNSEYNQLEVFISFLRKKLRFLKADIEIITTKGFGYSLEERT

Nucleotide

• Length: 675 bp

>NTDB_id=266331 DY328_RS02445 WP_001238594.1 458083..458757(-) (ciaR) [Streptococcus agalactiae strain Sag27]
ATGAGACTTCTTGTAGTTGAGGATGAAAAAAGTATAGCAGAGGCTATTCAGGCTTTATTGGCAGATAAAGGTTATTCTGT
TGATTTAGCATTTGATGGAGATGATGGGTTAGAATACATTTTGACAGGTCTCTATGATTTAGTCCTGTTGGATATTATGT
TACCCAAACGCTCAGGATTATCTGTTTTAAAAAGAGTGAGGGAAGCTGGTTTAGAAACCCCAATAATCTTTTTAACTGCA
AAATCACAGACTTATGATAAAGTTAATGGTTTAGATTTAGGGGCAGATGATTATATCACAAAACCCTTTGAAGCAGATGA
ATTGCTAGCTAGAATTAGGCTGAGAACCAGACAATCTTCTCTAATCAGAGCAAATCAATTGCGGCTTGGAAATATAAGGC
TTAACACAGATTCACATGAGCTAGAATCTAAAGAAAGTAGTGTAAAATTATCCAATAAAGAATTTCTCTTGATGGAAGTT
TTTATGCGAAATGCAAAGCAGATTATTCCTAAAAATCAGTTGATTTCTAAGGTTTGGGGACCTTCAGACAATTCAGAATA
TAACCAGTTAGAAGTATTTATTTCTTTTTTGCGAAAAAAATTGCGCTTTTTAAAAGCAGACATTGAAATAATAACCACTA
AGGGCTTTGGATATTCCTTGGAGGAGAGGACATAA

Domains

Predicted by InterProScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-220)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: P0A4I0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.838	99.107	0.375
ciaR	Streptococcus pneumoniae Rx1	37.387	99.107	0.371
ciaR	Streptococcus pneumoniae D39	37.387	99.107	0.371
ciaR	Streptococcus pneumoniae TIGR4	37.387	99.107	0.371
ciaR	Streptococcus pneumoniae R6	37.387	99.107	0.371
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366
covR	Streptococcus salivarius strain HSISS4	35.371	100	0.362