Detailed information NTG0026587

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LACR_RS11920
• Genome accession: NC_008527
• Coordinates: 2296262..2297293 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris subsp. cremoris SK11
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2291262..2302293

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LACR_RS11895 (LACR_2459)	-	2292465..2292962 (-)	498	WP_011677211.1	nitroreductase family protein	-
LACR_RS11900 (LACR_2460)	-	2292949..2293158 (-)	210	WP_011677212.1	hypothetical protein	-
LACR_RS11910 (LACR_2462)	-	2293446..2294336 (+)	891	WP_011675620.1	IS982-like element IS982B family transposase	-
LACR_RS11915	kwcM	2294443..2295762 (-)	1320	WP_014573366.1	KxxxW cyclic peptide radical SAM maturase	-
LACR_RS14850	-	2295830..2295904 (-)	75	Protein_2318	KxxxW-cyclized peptide pheromone	-
LACR_RS11920 (LACR_2463)	sepM	2296262..2297293 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
LACR_RS11925 (LACR_2464)	coaD	2297277..2297777 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
LACR_RS11930 (LACR_2465)	rsmD	2297825..2298364 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LACR_RS11935 (LACR_2466)	-	2298535..2299755 (-)	1221	WP_011677216.1	MFS transporter	-
LACR_RS11940 (LACR_2467)	lmrP	2299839..2301065 (-)	1227	Protein_2323	multidrug efflux MFS transporter LmrP	-
LACR_RS11945 (LACR_2468)	-	2301253..2301747 (+)	495	WP_050748315.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=26587 LACR_RS11920 WP_011677213.1 2296262..2297293(-) (sepM) [Lactococcus cremoris subsp. cremoris SK11]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=26587 LACR_RS11920 WP_011677213.1 2296262..2297293(-) (sepM) [Lactococcus cremoris subsp. cremoris SK11]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49