Detailed information NTG0262363

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: C0J00_RS07535
• Genome accession: NZ_CP025536
• Coordinates: 1489844..1492102 (+)
• Length: 752 a.a.
• NCBI ID: WP_104968301.1
• Uniprot ID: A0A2L0D5P3
• Organism: Streptococcus pluranimalium strain TH11417
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1492182..1493527	1489844..1492102	flank	80

Gene organization within MGE regions

Location: 1489844..1493527

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C0J00_RS07535 (C0J00_07540)	clpE	1489844..1492102 (+)	2259	WP_104968301.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
C0J00_RS07540 (C0J00_07545)	-	1492182..1493527 (+)	1346	WP_199773958.1	IS3 family transposase	-

Sequence

Protein

• Length: 752 a.a.
• Molecular weight: 83627.74 Da
• Isoelectric Point: 4.8345

>NTDB_id=262363 C0J00_RS07535 WP_104968301.1 1489844..1492102(+) (clpE) [Streptococcus pluranimalium strain TH11417]
MLCQNCQLNESTIHLYTNVNGKQKQVDLCQNCYQIMKTDPKNNLLSNLGRENASSSMNPFFDDFFGDLNNFRAFSGDLPN
SPKTQSGGQGGNNGIGNRHPNAPLGGAQQKPQGLLEEFGINITDIARQGDIDPVIGRDEEILRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDADVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRQDVILFIDEIHEIVGAG
NAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHHVKYSP
DAIEAAAILSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPQEIDQRLVEAENLKAQATRDEDYERAAYFRDQIAKYK
EMQAQKIDDHDTPVITEKNIEAIIEQKTNIPVGDLKEKEQSQLIHLADDLKSHVIGQDDAVDKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAREGRTNSVLNQLGDFFSPEFMN
RFDGIIEFKALEKENLLTIVDLMLKDVNDRLATNGLHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLE
NPSEKNLRAIMTSNGNIIIKSNTKAEAVVEEN

Nucleotide

• Length: 2259 bp

>NTDB_id=262363 C0J00_RS07535 WP_104968301.1 1489844..1492102(+) (clpE) [Streptococcus pluranimalium strain TH11417]
ATGCTTTGTCAAAATTGTCAATTAAACGAATCAACTATCCATTTATATACTAATGTTAATGGTAAACAGAAACAAGTCGA
TCTTTGCCAAAACTGTTATCAAATTATGAAAACAGATCCCAAAAACAACCTTTTATCTAATCTGGGTCGAGAAAACGCAT
CATCTTCTATGAATCCATTTTTTGATGATTTCTTCGGTGACTTAAATAACTTCCGTGCCTTCAGCGGTGACCTTCCAAAC
AGTCCTAAAACACAATCTGGTGGTCAGGGAGGAAACAATGGAATTGGAAATCGTCATCCAAATGCTCCACTAGGCGGTGC
TCAACAAAAGCCTCAAGGACTCTTAGAAGAGTTCGGTATTAATATCACTGATATTGCACGCCAAGGCGATATTGATCCCG
TTATTGGTCGCGATGAAGAAATCCTTCGTGTTATCGAAATTCTAAACCGTCGTACCAAAAATAATCCTGTCCTCATTGGT
GAGCCAGGTGTTGGTAAAACTGCTGTCGTTGAAGGACTGGCTCAAAAGATTGTTGACGCTGATGTTCCTCAAAAACTCCA
AGGAAAGCAAGTCATCCGTTTGGATGTTGTCAGCCTTGTTCAGGGGACAGGCATCCGTGGACAATTTGAAGAACGTATGC
AAAAACTCATGGAAGAAATCCGTAATCGTCAAGATGTGATTCTCTTCATTGATGAGATTCATGAGATTGTTGGTGCAGGT
AATGCTGGTGATGGAAACATGGACGCCGGCAATATCCTAAAACCTGCTCTAGCTCGTGGTGAGCTACAACTAGTCGGTGC
TACTACTCTCAATGAATATCGTATCATTGAAAAAGATGCTGCTCTGGAACGTCGTATGCAGCCCGTCAAAGTTGATGAGC
CAAGTGTTGAGGAAACTATCACCATCTTAAAAGGTATTCAACCAAAATACGAAGACTATCACCATGTCAAATATAGCCCT
GATGCGATTGAAGCGGCAGCTATCCTTTCAAATCGTTACATTCAAGATCGCTTCCTTCCAGATAAGGCTATCGATCTACT
TGATGAAGCTGGATCTAAAATGAATTTAACCTTAAATTTTGTTGATCCACAAGAAATCGATCAACGTCTGGTGGAAGCCG
AAAACCTCAAAGCTCAAGCGACTCGAGATGAAGATTATGAACGCGCAGCTTATTTCCGTGACCAAATTGCTAAATACAAA
GAAATGCAAGCGCAAAAAATCGATGACCACGATACTCCAGTCATCACTGAAAAAAATATCGAAGCCATCATTGAACAAAA
AACTAATATTCCAGTCGGCGATCTCAAAGAAAAAGAACAAAGTCAATTAATTCATTTGGCTGACGACCTTAAATCACACG
TTATTGGACAAGACGATGCTGTTGATAAAATTGCAAAAGCCATTCGTCGTAACCGTGTCGGACTTGGTTCGCCAAATCGC
CCAATCGGTTCCTTCCTCTTTGTTGGTCCAACTGGTGTCGGTAAAACTGAACTCTCAAAACAACTAGCAATCGAGCTCTT
TGGTTCAGCAGACAGCATGATTCGCTTTGATATGTCCGAGTACATGGAAAAACATGCCGTCGCCAAACTTGTCGGAGCTC
CTCCAGGTTATGTTGGTTATGAAGAAGCTGGTCAATTAACAGAAAAAGTTCGTCGCAATCCATACTCACTCATTCTCTTG
GATGAAGTTGAGAAAGCTCACCCAGATGTTATGCATATGTTCTTACAAGTTCTTGACGATGGTCGTTTGACTGATGGTCA
AGGCCGTACCGTTAGCTTCAAAGATACCATTATCATCATGACCTCGAATGCTGGAACAGGCAAGGTTGAAGCTTCTGTTG
GATTTGGAGCAGCTCGTGAAGGTCGTACCAACTCCGTTCTTAACCAACTTGGAGACTTCTTTAGCCCAGAATTCATGAAC
CGTTTTGACGGTATTATCGAATTCAAAGCCCTTGAAAAAGAAAATCTCCTTACTATTGTTGATCTCATGCTCAAAGATGT
CAATGATAGACTTGCTACCAACGGTCTTCACCTTGATGTCACCGAGAAAGTTAAGGAAAAATTGGTTGATCTTGGCTATG
ATCCAAAAATGGGAGCTCGTCCACTTCGCAGAACAATTCAAGACCATATCGAAGATGCTATCACAGATTTCTATCTTGAA
AATCCTTCAGAGAAAAATCTCCGTGCCATCATGACTTCTAATGGAAACATCATTATCAAATCAAATACGAAAGCTGAAGC
TGTCGTAGAAGAAAACTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (295-392)

• ATPase family associated with various cellular activities (AAA) (AAA) (157-276)

• AAA domain (Cdc48 subfamily) (AAA_2) (480-643)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (651-726)

3D structure

• AlphaFold DB: A0A2L0D5P3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	86.551	99.867	0.864
clpE	Streptococcus pneumoniae Rx1	82.781	100	0.831
clpE	Streptococcus pneumoniae D39	82.781	100	0.831
clpE	Streptococcus pneumoniae R6	82.781	100	0.831
clpE	Streptococcus pneumoniae TIGR4	82.781	100	0.831
clpC	Lactococcus lactis subsp. cremoris KW2	75.733	99.734	0.755
clpC	Bacillus subtilis subsp. subtilis str. 168	49.354	92.686	0.457
clpC	Streptococcus pneumoniae Rx1	47.368	83.378	0.395
clpC	Streptococcus pneumoniae D39	47.368	83.378	0.395
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.468	84.707	0.394
clpC	Streptococcus pneumoniae TIGR4	47.209	83.378	0.394
clpC	Streptococcus mutans UA159	47.182	82.58	0.39
clpC	Streptococcus thermophilus LMD-9	46.057	84.309	0.388
clpC	Streptococcus thermophilus LMG 18311	45.728	84.043	0.384