Detailed information NTG0262027

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A7U46_RS11585
• Genome accession: NZ_CP025495
• Coordinates: 2217684..2218727 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 3020.C01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2212684..2223727

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7U46_RS11540 (A7U46_011540)	-	2213054..2213164 (+)	111	WP_001790257.1	hypothetical protein	-
A7U46_RS11545 (A7U46_011545)	-	2213193..2213606 (+)	414	WP_001549145.1	hypothetical protein	-
A7U46_RS11555 (A7U46_011555)	-	2214096..2215082 (-)	987	WP_000999713.1	FUSC family protein	-
A7U46_RS11570 (A7U46_011570)	map	2215610..2216368 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A7U46_RS11575 (A7U46_011575)	-	2216585..2216971 (+)	387	WP_001110179.1	hypothetical protein	-
A7U46_RS11580 (A7U46_011580)	liaF	2216986..2217687 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A7U46_RS11585 (A7U46_011585)	vraS	2217684..2218727 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A7U46_RS11590 (A7U46_011590)	vraR	2218717..2219346 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
A7U46_RS11595 (A7U46_011595)	-	2219462..2220679 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
A7U46_RS11600 (A7U46_011600)	-	2220957..2221232 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
A7U46_RS11605 (A7U46_011605)	-	2221239..2221703 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A7U46_RS11610 (A7U46_011610)	-	2221850..2222050 (+)	201	WP_000180461.1	DUF1128 family protein	-
A7U46_RS11615 (A7U46_011615)	-	2222053..2223309 (+)	1257	WP_078149050.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=262027 A7U46_RS11585 WP_001017131.1 2217684..2218727(+) (vraS) [Staphylococcus aureus strain 3020.C01]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=262027 A7U46_RS11585 WP_001017131.1 2217684..2218727(+) (vraS) [Staphylococcus aureus strain 3020.C01]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1