Detailed information NTG0260859

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAO46_RS10215
• Genome accession: NZ_CP025395
• Coordinates: 1998449..1999492 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus O46
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1993449..2004492

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAO46_RS10185 (SAO46_01858)	-	1993870..1995126 (-)	1257	WP_078071269.1	aminopeptidase	-
SAO46_RS10190 (SAO46_01859)	-	1995129..1995329 (-)	201	WP_000180460.1	DUF1128 family protein	-
SAO46_RS10195 (SAO46_01860)	-	1995476..1995940 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SAO46_RS10200 (SAO46_01861)	-	1995947..1996222 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAO46_RS10205 (SAO46_01862)	-	1996500..1997717 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
SAO46_RS10210 (SAO46_01863)	vraR	1997830..1998459 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SAO46_RS10215 (SAO46_01864)	vraS	1998449..1999492 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAO46_RS10220 (SAO46_01865)	liaF	1999489..2000190 (-)	702	WP_000149070.1	cell wall-active antibiotics response protein LiaF	-
SAO46_RS10225 (SAO46_01866)	-	2000205..2000591 (-)	387	WP_001110179.1	hypothetical protein	-
SAO46_RS10230 (SAO46_01867)	map	2000808..2001566 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAO46_RS10240 (SAO46_01869)	-	2002152..2003138 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SAO46_RS10245 (SAO46_01870)	-	2003327..2003740 (-)	414	WP_025174666.1	hypothetical protein	-
SAO46_RS10250	-	2003769..2003879 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=260859 SAO46_RS10215 WP_001017131.1 1998449..1999492(-) (vraS) [Staphylococcus aureus O46]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=260859 SAO46_RS10215 WP_001017131.1 1998449..1999492(-) (vraS) [Staphylococcus aureus O46]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1