Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HAC_RS03170 Genome accession   NC_008229
Coordinates   634928..636712 (+) Length   594 a.a.
NCBI ID   WP_011577638.1    Uniprot ID   Q17XV1
Organism   Helicobacter acinonychis str. Sheeba     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 629928..641712
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HAC_RS03135 (Hac_0718) motA 629929..630702 (+) 774 WP_011577632.1 flagellar motor stator protein MotA -
  HAC_RS03140 (Hac_0719) motB 630705..631466 (+) 762 WP_011577633.1 flagellar motor protein MotB -
  HAC_RS03145 (Hac_0720) - 631480..631911 (+) 432 WP_011577634.1 hypothetical protein -
  HAC_RS03150 (Hac_0721) - 631980..633635 (+) 1656 WP_011577635.1 ABC transporter permease/substrate-binding protein -
  HAC_RS03155 (Hac_0722) - 633639..634289 (+) 651 WP_011577636.1 ABC transporter ATP-binding protein -
  HAC_RS03160 - 634295..634474 (-) 180 WP_041600190.1 hypothetical protein -
  HAC_RS03165 (Hac_0724) - 634466..634927 (+) 462 WP_011577637.1 hypothetical protein -
  HAC_RS03170 (Hac_0725) uvrC 634928..636712 (+) 1785 WP_011577638.1 excinuclease ABC subunit UvrC Machinery gene
  HAC_RS03175 (Hac_0726) - 636723..637988 (+) 1266 WP_011577639.1 homoserine dehydrogenase -
  HAC_RS03180 (Hac_0727) - 637989..638333 (+) 345 WP_011577640.1 YraN family protein -
  HAC_RS03185 (Hac_0728) trxA 638420..638740 (+) 321 WP_011577641.1 thioredoxin -
  HAC_RS03190 (Hac_0729) trxB 638746..639681 (+) 936 WP_011577642.1 thioredoxin-disulfide reductase -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68802.05 Da        Isoelectric Point: 9.7498

>NTDB_id=26070 HAC_RS03170 WP_011577638.1 634928..636712(+) (uvrC) [Helicobacter acinonychis str. Sheeba]
MADLLSSLKNLSNGSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQLGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELQLKMDRLSSNLRFEEALIYRDRISKIQKI
APFTCMDLAKLYDLDIFAFYGKNNRAVLVKMFMRGGKIISSAFEKIHSLNGFDADEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFIYHKHSKKITLNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEEEILEEVRSLLNLECVPYRVEIFDT
SHHANSQCVGGMVVYENSAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALETLKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTMSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKIKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=26070 HAC_RS03170 WP_011577638.1 634928..636712(+) (uvrC) [Helicobacter acinonychis str. Sheeba]
ATGGCTGATTTATTGTCCAGTTTAAAAAACCTTTCTAATGGCAGTGGGGTGTATCAATACTTTGATAAAAACCGCCAATT
ACTCTACATCGGTAAAGCAAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ATCATCGCACAAGTTTGCGCATTCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACAATTTTAGTAGAAAACGAGCAA
GACGCTTTGATTTTAGAGAATTCTTTAATCAAGCAACTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGACTTTCCTATTCCTTTAATCACACGAAAAATTTTAAAACAGCTTGGCGTTA
AATATTTTGGCCCTTTTACTAGTGGGGCTAAAGATATTTTGGATAGCTTGTATGAATTGCTCCCTTTAGTTCAAAAGAAA
AATTGCATTAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCTCCATGCGAGAATAAAATCACCAA
AGAAGAATATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAGCTCATCAAAGAACTTCAATTAA
AAATGGATCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCTCTCATTTATAGAGACAGGATTTCTAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCAAAAACAACAGGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAATGGGTTTGATG
CTGATGAAGCGATGAAACAAGCGATCATTAACCATTACCAATCGCATTTGCCTTTAATGCCTGAACAAATTCTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATTTATCATAAACACTCTAAAAAAATCACTCTTAATATCCC
CAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ACGAAGAAGAAATCTTAGAAGAGGTGCGCTCGCTTTTAAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAGTGCATTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGAGCCTTAGATTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATAGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAACTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGATGAGCGATACTTTTAAATTGCTCCCTAGTGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACCGATCCACTAAAATTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAAGAAAAAAA
CGCCGTTTTGAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(16-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(384-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q17XV1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

94.098

99.832

0.939

Multiple sequence alignment