Detailed information NTG0260135

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: CXR48_RS00580
• Genome accession: NZ_CP025341
• Coordinates: 104708..107140 (+)
• Length: 810 a.a.
• NCBI ID: WP_007410388.1
• Uniprot ID: I2C0L0
• Organism: Bacillus velezensis strain CMT-6
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 99708..112140

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CXR48_RS00565	ctsR	102585..103049 (+)	465	WP_003156396.1	transcriptional regulator CtsR	-
CXR48_RS00570	-	103063..103620 (+)	558	WP_003156397.1	UvrB/UvrC motif-containing protein	-
CXR48_RS00575	-	103620..104711 (+)	1092	WP_003156398.1	protein arginine kinase	-
CXR48_RS00580	clpC	104708..107140 (+)	2433	WP_007410388.1	ATP-dependent protease ATP-binding subunit ClpC	Regulator
CXR48_RS00585	radA	107234..108613 (+)	1380	WP_014304212.1	DNA repair protein RadA	Machinery gene
CXR48_RS00590	disA	108617..109699 (+)	1083	WP_003156401.1	DNA integrity scanning diadenylate cyclase DisA	-
CXR48_RS00595	-	109813..110913 (+)	1101	WP_003156403.1	PIN/TRAM domain-containing protein	-
CXR48_RS00600	ispD	110926..111624 (+)	699	WP_063174315.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
CXR48_RS00605	ispF	111617..112093 (+)	477	WP_003156407.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90013.46 Da
• Isoelectric Point: 5.9514

>NTDB_id=260135 CXR48_RS00580 WP_007410388.1 104708..107140(+) (clpC) [Bacillus velezensis strain CMT-6]
MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSDKIQKEVESLIGRGQEMSQTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSASGTNSNANT
PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVM
TLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEY
RKYIEKDAALERRFQPIQVDQPSADESIQILKGLRDRYEAHHRVSITDEAIEAAVKLSDRYISDRFLPDKAIDLIDEAGS
KVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKTWKEKQGQENSEVSVEDIAMVV
SSWTGVPVSKIAQTETDKLLNMESILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
SIFGDEEAMIRVDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLT
DSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDESQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLT
DIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIDKGQHIVLDVEDGE
FVVKTTAKTN

Nucleotide

• Length: 2433 bp

>NTDB_id=260135 CXR48_RS00580 WP_007410388.1 104708..107140(+) (clpC) [Bacillus velezensis strain CMT-6]
ATGATGTTTGGAAGGTTTACAGAGCGAGCTCAAAAGGTATTGGCACTGGCACAGGAGGAAGCACTGCGCTTAGGCCATAA
CAATATTGGAACTGAACATATCTTATTAGGTCTGGTTCGTGAAGGAGAAGGGATTGCGGCTAAAGCACTCCAAGCACTCG
GACTCGGTTCGGATAAAATTCAGAAAGAAGTGGAGAGCTTAATCGGACGGGGACAGGAAATGTCTCAAACGATTCATTAT
ACGCCAAGAGCAAAAAAAGTCATTGAGCTCAGCATGGATGAAGCCAGAAAGCTAGGACATTCTTATGTGGGAACAGAACA
CATACTTCTCGGATTGATCCGTGAAGGAGAAGGCGTGGCGGCGAGAGTTCTGAATAATCTCGGTGTCAGCTTAAATAAAG
CGAGACAGCAAGTGCTGCAGCTTCTGGGAAGCAATGAGACGGGGTCTTCTGCATCCGGTACCAACAGCAATGCAAACACG
CCGACGCTTGACAGTCTGGCGCGTGATTTAACTGCGATTGCGAAGGAAGACAGTCTTGATCCGGTTATCGGGCGAAGCAA
AGAAATTCAGCGTGTTATTGAGGTATTAAGCCGCAGAACGAAAAATAATCCCGTTCTTATCGGAGAACCGGGTGTAGGTA
AAACTGCGATTGCTGAAGGCCTCGCACAGCAGATCATCAATAATGAAGTGCCGGAAATTTTACGTGATAAACGCGTAATG
ACGTTAGACATGGGTACGGTTGTAGCCGGTACGAAATACCGCGGAGAATTTGAAGACCGCTTGAAAAAAGTAATGGATGA
AATACGTCAGGCCGGCAATATTATTTTATTCATTGACGAACTGCATACACTGATCGGAGCGGGGGGAGCAGAAGGTGCGA
TTGACGCATCGAATATTTTAAAACCTTCACTGGCCCGCGGAGAGCTTCAATGCATCGGTGCCACAACGCTTGATGAATAC
CGTAAATATATCGAAAAAGACGCGGCTCTCGAGCGCCGTTTCCAGCCGATTCAGGTGGATCAGCCGTCAGCCGATGAAAG
CATTCAAATTTTAAAAGGGCTCCGTGACCGCTATGAAGCGCATCACCGCGTATCCATTACCGATGAAGCGATCGAAGCCG
CGGTTAAATTGTCCGACCGTTATATTTCTGACCGCTTCCTTCCGGATAAAGCGATCGATTTAATTGATGAAGCCGGTTCA
AAAGTGCGTCTCCGTTCTTTCACAACGCCTCCGAACTTAAAAGAGCTTGAGCAGAAACTCGATGAAGTTCGCAAGGAAAA
AGACGCTGCCGTTCAGAGCCAGGAGTTTGAAAAAGCGGCTTCCCTTCGTGATACGGAGCAGCGCCTGAGAGAACAGGTGG
AAGACACGAAAAAAACCTGGAAAGAAAAACAAGGCCAGGAGAACTCCGAAGTTTCTGTAGAGGATATCGCGATGGTTGTA
TCCAGCTGGACCGGGGTGCCCGTATCTAAAATTGCCCAAACGGAAACAGATAAGCTTCTCAATATGGAAAGCATTCTGCA
TTCCCGCGTCATCGGCCAGGATGAAGCCGTTGTAGCCGTGGCAAAGGCTGTCAGACGTGCAAGAGCCGGACTGAAGGACC
CGAAACGTCCGATTGGTTCATTCATCTTCTTAGGCCCTACAGGCGTTGGGAAGACAGAGCTGGCAAGAGCGCTGGCGGAA
TCCATTTTCGGTGATGAGGAAGCGATGATCAGAGTGGATATGTCCGAATACATGGAGAAACACTCGACTTCACGTCTTGT
CGGTTCTCCTCCGGGATATGTCGGCTATGATGAAGGCGGCCAGCTGACAGAAAAAGTGAGAAGAAAACCTTACTCTGTCG
TATTGCTTGATGAAATTGAAAAAGCACACCCTGATGTGTTTAACATTCTCCTGCAAGTGCTTGAAGACGGACGCTTGACT
GATTCAAAAGGACGCACTGTGGATTTCCGCAACACGATCCTGATTATGACGTCAAACGTCGGGGCGAGCGAGCTGAAGCG
CAACAAATATGTAGGCTTCAATGTCCAGGATGAATCACAAAACCATAAAGACATGAAAGACAAAGTCATGGGAGAGTTGA
AGCGTGCCTTCAGACCTGAGTTTATCAACCGGATTGACGAAATTATCGTCTTCCACTCCCTTGAGAAAAAACATCTTACA
GACATCGTGTCGCTTATGTCTGATCAGTTAACAAAACGTCTGAAAGAACAAGATCTCTCTATCGAGCTGACGGATGCTGC
CAAAGCAAAAGTAGCAGAAGAGGGCGTCGATTTGGAATACGGCGCACGTCCGTTAAGAAGAGCGATTCAAAAGCATGTGG
AGGACCGGTTATCAGAAGAACTCCTCAGAGGCAATATTGATAAAGGCCAACACATTGTTCTTGATGTTGAGGACGGCGAA
TTTGTCGTAAAAACAACTGCTAAAACGAACTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (343-444)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (714-793)

• ATPase family associated with various cellular activities (AAA) (AAA) (205-317)

• AAA domain (Cdc48 subfamily) (AAA_2) (536-708)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-69)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-143)

3D structure

• AlphaFold DB: I2C0L0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	98.272	100	0.983
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.875	98.765	0.493
clpC	Streptococcus thermophilus LMD-9	46.845	100	0.477
clpC	Streptococcus thermophilus LMG 18311	46.602	100	0.474
clpC	Streptococcus pneumoniae Rx1	45.117	99.877	0.451
clpC	Streptococcus pneumoniae D39	45.117	99.877	0.451
clpC	Streptococcus mutans UA159	43.947	100	0.448
clpC	Streptococcus pneumoniae TIGR4	44.87	99.877	0.448
clpE	Streptococcus mutans UA159	53.313	80.123	0.427
clpC	Lactococcus lactis subsp. cremoris KW2	49.709	84.938	0.422
clpE	Streptococcus pneumoniae TIGR4	52.388	80.123	0.42
clpE	Streptococcus pneumoniae Rx1	52.388	80.123	0.42
clpE	Streptococcus pneumoniae D39	52.388	80.123	0.42
clpE	Streptococcus pneumoniae R6	52.388	80.123	0.42