Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPAG1_RS04065 Genome accession   NC_008086
Coordinates   841444..843228 (+) Length   594 a.a.
NCBI ID   WP_000774351.1    Uniprot ID   Q1CT48
Organism   Helicobacter pylori HPAG1     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 836444..848228
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPAG1_RS04030 (HPAG1_0801) motB 837209..837982 (+) 774 WP_001085294.1 flagellar motor protein MotB -
  HPAG1_RS04035 (HPAG1_0802) - 837988..838425 (+) 438 WP_001883762.1 hypothetical protein -
  HPAG1_RS04045 (HPAG1_0804) - 838494..840156 (+) 1663 Protein_782 ABC transporter permease/substrate-binding protein -
  HPAG1_RS04050 (HPAG1_0805) - 840158..840799 (+) 642 WP_000659351.1 ATP-binding cassette domain-containing protein -
  HPAG1_RS04055 - 840811..840990 (-) 180 WP_000468794.1 hypothetical protein -
  HPAG1_RS04060 (HPAG1_0806) - 840982..841443 (+) 462 WP_000812331.1 hypothetical protein -
  HPAG1_RS04065 (HPAG1_0807) uvrC 841444..843228 (+) 1785 WP_000774351.1 excinuclease ABC subunit UvrC Machinery gene
  HPAG1_RS04070 (HPAG1_0808) - 843239..844504 (+) 1266 WP_000746831.1 homoserine dehydrogenase -
  HPAG1_RS04075 (HPAG1_0809) - 844504..844848 (+) 345 WP_001211674.1 YraN family protein -
  HPAG1_RS04080 (HPAG1_0810) trxA 844937..845257 (+) 321 WP_000020199.1 thioredoxin -
  HPAG1_RS04085 (HPAG1_0811) trxB 845262..846197 (+) 936 WP_000564430.1 thioredoxin-disulfide reductase -
  HPAG1_RS04090 (HPAG1_0812) - 846407..847228 (+) 822 WP_001263459.1 glycosyltransferase family 25 protein -
  HPAG1_RS04095 (HPAG1_0813) - 847431..847679 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68631.73 Da        Isoelectric Point: 9.5806

>NTDB_id=25964 HPAG1_RS04065 WP_000774351.1 841444..843228(+) (uvrC) [Helicobacter pylori HPAG1]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENRDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSDEDLILEEVRSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=25964 HPAG1_RS04065 WP_000774351.1 841444..843228(+) (uvrC) [Helicobacter pylori HPAG1]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGGGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAACAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAGAGACAAGCTCATCAAGGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGACATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTACCTTTGATGCCTGAACAGATCTTGTTGAGC
GCTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTG
ATGAAGATCTGATTTTAGAAGAGGTGCGATCGCTCTTTAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAAACTCTTACCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCACAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATCAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q1CT48

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.306

100

0.973

Multiple sequence alignment