Detailed information NTG0025857

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MGAS9429_RS06080
• Genome accession: NC_008021
• Coordinates: 1215088..1216125 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes MGAS9429
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1210088..1221125

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS9429_RS06055 (MGAS9429_Spy1254)	-	1210092..1210619 (-)	528	WP_002983837.1	Dps family protein	-
MGAS9429_RS06060 (MGAS9429_Spy1255)	-	1210847..1211473 (+)	627	WP_002989076.1	prepilin peptidase	-
MGAS9429_RS06065 (MGAS9429_Spy1256)	rlmN	1211555..1212634 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
MGAS9429_RS06070 (MGAS9429_Spy1257)	-	1212638..1213258 (-)	621	WP_032461520.1	YutD family protein	-
MGAS9429_RS06075 (MGAS9429_Spy1259)	-	1213706..1214683 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
MGAS9429_RS06080 (MGAS9429_Spy1260)	sepM	1215088..1216125 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
MGAS9429_RS06085 (MGAS9429_Spy1261)	coaD	1216112..1216603 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
MGAS9429_RS06090 (MGAS9429_Spy1262)	rsmD	1216593..1217132 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MGAS9429_RS06095 (MGAS9429_Spy1263)	asnA	1217255..1218247 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
MGAS9429_RS06100 (MGAS9429_Spy1264)	arcC	1218561..1219511 (-)	951	WP_002989065.1	carbamate kinase	-
MGAS9429_RS06105 (MGAS9429_Spy1265)	-	1219531..1220862 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=25857 MGAS9429_RS06080 WP_002989068.1 1215088..1216125(-) (sepM) [Streptococcus pyogenes MGAS9429]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=25857 MGAS9429_RS06080 WP_002989068.1 1215088..1216125(-) (sepM) [Streptococcus pyogenes MGAS9429]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69