Detailed information NTG0025846

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: PA14_RS12135
• Genome accession: NC_008463
• Coordinates: 2573895..2574566 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa UCBPP-PA14
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2568895..2579566

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PA14_RS12100 (PA14_29650)	ppyR	2569368..2569625 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
PA14_RS12105 (PA14_29660)	-	2569612..2570805 (+)	1194	WP_003138915.1	NnrS family protein	-
PA14_RS12110	-	2570806..2571072 (-)	267	WP_003090500.1	DUF5329 domain-containing protein	-
PA14_RS12115 (PA14_29680)	-	2571056..2571949 (-)	894	WP_003131077.1	hypothetical protein	-
PA14_RS12120 (PA14_29690)	-	2571976..2573058 (-)	1083	WP_003138917.1	hypothetical protein	-
PA14_RS12125 (PA14_29710)	-	2573273..2573581 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
PA14_RS12130 (PA14_29720)	-	2573581..2573895 (+)	315	WP_003097704.1	PepSY domain-containing protein	-
PA14_RS12135 (PA14_29730)	ciaR	2573895..2574566 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
PA14_RS12140 (PA14_29740)	carS	2574563..2575900 (+)	1338	WP_003097701.1	two-component system sensor histidine kinase CarS	-
PA14_RS12145 (PA14_29750)	-	2575991..2576299 (+)	309	WP_003097699.1	hypothetical protein	-
PA14_RS31755	-	2576304..2576840 (-)	537	Protein_2414	methyl-accepting chemotaxis protein	-
PA14_RS31760	-	2577162..2578448 (-)	1287	Protein_2415	HAMP domain-containing protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=25846 PA14_RS12135 WP_003090494.1 2573895..2574566(+) (ciaR) [Pseudomonas aeruginosa UCBPP-PA14]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=25846 PA14_RS12135 WP_003090494.1 2573895..2574566(+) (ciaR) [Pseudomonas aeruginosa UCBPP-PA14]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGACCTGATCATTCTCGACCTCGGCC
TGCCCGGGCGTCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGCCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTATCTGACCAAGCCGTTCCATCCGGAAGA
GTTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC
GCCTGGACGAGCAGCGTCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363