Detailed information NTG0257633

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: CWI26_RS11910
• Genome accession: NZ_CP025043
• Coordinates: 2401890..2403086 (+)
• Length: 398 a.a.
• NCBI ID: WP_024376048.1
• Uniprot ID: A0A2I5KS08
• Organism: Streptococcus suis strain AH681
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2396890..2408086

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CWI26_RS11870 (CWI26_11870)	tnpB	2398094..2398444 (+)	351	WP_002941575.1	IS66 family insertion sequence element accessory protein TnpB	-
CWI26_RS11875 (CWI26_11875)	-	2398496..2398702 (+)	207	WP_002941576.1	hypothetical protein	-
CWI26_RS11880 (CWI26_11880)	-	2398656..2400008 (+)	1353	WP_100881188.1	IS66-like element short variant transposase	-
CWI26_RS11900 (CWI26_11900)	-	2400529..2401212 (-)	684	WP_024376049.1	YoaK family protein	-
CWI26_RS11905 (CWI26_11905)	rlmH	2401237..2401716 (-)	480	WP_002941741.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
CWI26_RS11910 (CWI26_11910)	htrA	2401890..2403086 (+)	1197	WP_024376048.1	S1C family serine protease	Regulator
CWI26_RS11915 (CWI26_11915)	spo0J	2403147..2403911 (+)	765	WP_012775418.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41822.88 Da
• Isoelectric Point: 4.5454

>NTDB_id=257633 CWI26_RS11910 WP_024376048.1 2401890..2403086(+) (htrA) [Streptococcus suis strain AH681]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSTITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSEDGQTISTNAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKITSSSVSSSGVAVEGMGFAIPANDAVAIINQLEKAGKVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=257633 CWI26_RS11910 WP_024376048.1 2401890..2403086(+) (htrA) [Streptococcus suis strain AH681]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTCTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAACCACAGGTTCAACAAGCAAATTCTACTATCACTAGTGTCAGCAATGTTCAATACA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAATCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTCATTAATAACGCAGAAAAGATTGATATTCTTT
TAGCATCTGGAGAAAAAATCAGCGGTGAACTCGTTGGTTCCGATACCTATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCTAATACAGTTACTCAAGGTATTATTTCTAGCCTAAGTAGGACAGTTACTTCACAATCAGAAG
ATGGTCAAACAATCTCAACCAACGCTATTCAAACCGATACAGCTATCAACCCTGGAAACTCTGGAGGACCATTGATTAAT
ATCCAAGGACAAGTTATTGGTATCACCTCTAGCAAAATCACCTCAAGTTCTGTAAGTAGCTCAGGTGTGGCTGTGGAAGG
GATGGGATTTGCTATTCCTGCAAATGATGCCGTAGCCATTATCAATCAACTTGAGAAAGCTGGAAAAGTTAGCAGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTGGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCTGGTGTCGTAATTGTCTCTACACAAAGTGGACTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (293-389)

3D structure

• AlphaFold DB: A0A2I5KS08

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	60.453	99.749	0.603
htrA	Streptococcus gordonii str. Challis substr. CH1	60.506	99.246	0.6
htrA	Streptococcus pneumoniae Rx1	57.506	98.744	0.568
htrA	Streptococcus pneumoniae D39	57.506	98.744	0.568
htrA	Streptococcus pneumoniae R6	57.506	98.744	0.568
htrA	Streptococcus pneumoniae TIGR4	57.506	98.744	0.568
htrA	Streptococcus mitis NCTC 12261	57.506	98.744	0.568