Detailed information NTG0257630

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: CWI26_RS10720
• Genome accession: NZ_CP025043
• Coordinates: 2176259..2178709 (-)
• Length: 816 a.a.
• NCBI ID: WP_100881763.1
• Uniprot ID: A0A2I5KRD3
• Organism: Streptococcus suis strain AH681
• Function: degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 2171259..2183709

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CWI26_RS10710 (CWI26_10710)	-	2175244..2175681 (-)	438	WP_233486255.1	hypothetical protein	-
CWI26_RS10715 (CWI26_10715)	-	2175753..2176250 (-)	498	WP_100881762.1	GNAT family N-acetyltransferase	-
CWI26_RS10720 (CWI26_10720)	clpC	2176259..2178709 (-)	2451	WP_100881763.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
CWI26_RS10725 (CWI26_10725)	-	2178713..2179171 (-)	459	WP_099810173.1	CtsR family transcriptional regulator	-
CWI26_RS10730 (CWI26_10730)	-	2179441..2179779 (+)	339	WP_100881764.1	thioredoxin domain-containing protein	-
CWI26_RS10735 (CWI26_10735)	-	2179779..2180405 (+)	627	WP_100881765.1	GNAT family acetyltransferase	-
CWI26_RS10745 (CWI26_10745)	tsf	2180958..2181998 (-)	1041	WP_029186461.1	translation elongation factor Ts	-
CWI26_RS10750 (CWI26_10750)	rpsB	2182266..2183042 (-)	777	WP_012775356.1	30S ribosomal protein S2	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90343.89 Da
• Isoelectric Point: 6.2908

>NTDB_id=257630 CWI26_RS10720 WP_100881763.1 2176259..2178709(-) (clpC) [Streptococcus suis strain AH681]
MKISTGLQRVFEDAQLVAQRYACDYLETWHVLLSFVINHDTVAGAVLAEYPISISDYEHATFVVTDKVYREELDSFRILP
SSKRLDETASFAKKIAEVVKAKELGTEHLFMAMLLDKRSTASQILDKVGFCFEDSDDKFRFLDLRKNLEARAGFTKEDLK
AIRSVMKGGKAKPTNMGQMMGMPPAPQSGGLEDYTRDLTALAREGKIEPVIGRDAEIARMIQILSRKTKNNPVLVGDAGV
GKTALALGLAQRVAAGDVPVSLAKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQTEYQKHIEKDAALVRRFAKVTIEEPTVEDSIAILTGLKGTFEKYHRVRIGQAAV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRVKGQAEETGLTSIDKALMDKKYKTVSKLLIKTKEDAEASQNYDLEV
TEEDVLETLSRLSGIPVAKLSQSDTKKYLNLEAELHKRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGVGK
TELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLL
QVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKVVF
HSLTESHMQDVVKVMIKPLLAVTAEKGITLKLQPSALKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGDLATGST
LKVGVKGEELKFDVVK

Nucleotide

• Length: 2451 bp

>NTDB_id=257630 CWI26_RS10720 WP_100881763.1 2176259..2178709(-) (clpC) [Streptococcus suis strain AH681]
ATGAAAATTTCAACTGGTTTACAGCGGGTTTTTGAAGATGCCCAGTTAGTGGCCCAACGTTATGCCTGTGATTACTTGGA
AACCTGGCATGTTCTCTTGTCTTTCGTTATCAACCATGATACAGTCGCCGGCGCTGTTTTGGCAGAATATCCTATTTCAA
TTTCTGACTATGAACATGCAACTTTTGTTGTGACCGACAAGGTCTATCGTGAAGAGTTGGATAGTTTTCGTATTTTACCA
TCTTCTAAACGTTTGGATGAAACAGCTAGTTTTGCCAAGAAAATTGCAGAAGTCGTCAAGGCTAAGGAGTTGGGAACGGA
ACATTTGTTTATGGCTATGTTGTTGGACAAGCGTTCAACAGCTAGTCAGATTTTGGACAAGGTAGGTTTTTGTTTTGAAG
ACTCAGATGATAAGTTTCGTTTCTTGGATTTGCGTAAAAACTTGGAGGCACGTGCGGGATTTACCAAAGAGGACCTTAAA
GCTATCCGCAGTGTGATGAAGGGTGGCAAAGCCAAACCTACTAATATGGGACAGATGATGGGAATGCCCCCAGCACCTCA
AAGTGGTGGCTTAGAGGACTACACTCGTGATTTGACAGCTTTGGCGCGTGAAGGGAAGATTGAACCTGTCATCGGTCGAG
ACGCTGAGATTGCACGGATGATCCAAATTCTATCACGTAAAACCAAGAATAACCCAGTTCTAGTTGGTGATGCTGGTGTC
GGAAAAACTGCGCTTGCTTTGGGTCTTGCTCAACGTGTTGCTGCAGGTGATGTCCCTGTCAGCTTGGCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAACGTTATCGCTGGAACTCGTTTCCGTGGTGATTTCGAAGAGCGGATGAATAATATCATCA
ACGACATCGAGGAAGATGGTCAGGTCATCCTTTTCATCGATGAGTTGCATACCATTATGGGTTCTGGCTCGGGGATTGAT
TCGACCTTGGATGCAGCCAATATCCTCAAACCAGCTCTTGCTCGTGGCACCCTCCGTACGGTCGGAGCGACGACTCAGAC
AGAGTACCAAAAGCATATTGAGAAAGACGCAGCCTTGGTTCGCCGTTTTGCCAAAGTGACCATTGAAGAGCCGACAGTGG
AAGATAGCATTGCCATTTTGACTGGTTTAAAAGGTACTTTTGAGAAATACCACAGGGTCCGTATTGGACAAGCAGCTGTA
GAGACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCAGCCATTGATTTGCTGGATGAAGC
TAGTGCAACGGTACAAAATCGAGTGAAAGGGCAGGCTGAGGAAACAGGACTGACGAGTATTGACAAGGCCTTGATGGATA
AAAAATATAAGACTGTCAGCAAGCTTTTGATTAAAACGAAAGAAGATGCCGAGGCTAGTCAAAACTATGACCTTGAAGTA
ACAGAAGAAGATGTTTTAGAAACACTTAGCCGCTTGTCAGGTATTCCTGTAGCCAAGCTCAGTCAGTCAGATACCAAGAA
ATATCTGAATTTGGAAGCAGAATTGCACAAGCGTGTGATTGGTCAGGAAGAAGCTATTTCTGCAGTCAGCAGAGCTATCC
GTCGTAATCAGTCAGGTATTCGAACAGGTCGCAGACCGATTGGTTCATTCATGTTCTTGGGACCGACGGGTGTCGGTAAG
ACGGAGCTTGCCAAGGCCTTAGCAGAAGTACTCTTTGATGATGAATCAGCCCTTATCCGCTTTGACATGTCTGAATACAT
GGAGAAATTCGCAGCCAGCCGTTTAAATGGTGCTCCTCCGGGCTATGTGGGCTATGAAGAAGGTGGCGAATTGACGGAGA
AAGTCCGCAACAAACCTTATTCTGTTCTTCTCTTTGACGAGGTAGAGAAAGCTCATCCAGATATTTTCAATGTGCTCTTG
CAGGTCTTAGATGATGGTGTCTTAACAGACAGTAAGGGACGCAAGGTGGATTTCTCCAATACCATCATTATCATGACGTC
TAACCTTGGAGCAACAGCCCTTCGTGATGATAAGACAGTTGGTTTTGGTGCCCTTGATTTATCTAAGGACCACAAGGAAG
TGGAGAAACGCATTTTTGAGGAATTGAAAAAAGCCTATCGTCCAGAATTTATCAACCGTATTGACGAGAAAGTTGTCTTC
CATAGCTTGACAGAATCCCATATGCAGGATGTTGTCAAGGTCATGATTAAACCTTTGTTGGCTGTAACAGCTGAGAAAGG
AATTACCCTTAAACTGCAACCGTCAGCCCTTAAGTTATTAGCTAAACAAGGTTACGACCCAGAAATGGGAGCTCGTCCAC
TTCGTAGACTCTTACAAACCAAATTGGAAGACCCATTGGCAGAAATGTTGCTCCGTGGTGACTTGGCTACTGGTTCGACC
TTGAAGGTTGGGGTCAAGGGCGAAGAACTCAAATTTGATGTGGTCAAATAG

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-803)

• ATPase family associated with various cellular activities (AAA) (AAA) (233-365)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (102-129)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-56)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• AAA lid domain (AAA_lid_9) (372-457)

3D structure

• AlphaFold DB: A0A2I5KRD3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	71.902	99.877	0.718
clpC	Streptococcus pneumoniae D39	71.902	99.877	0.718
clpC	Streptococcus pneumoniae TIGR4	71.902	99.877	0.718
clpC	Streptococcus mutans UA159	66.83	99.755	0.667
clpC	Streptococcus thermophilus LMD-9	63.962	100	0.657
clpC	Streptococcus thermophilus LMG 18311	64.38	100	0.656
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.222	100	0.504
clpC	Bacillus subtilis subsp. subtilis str. 168	43.353	100	0.444