Detailed information NTG0257509

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CWR44_RS12345
• Genome accession: NZ_CP025031
• Coordinates: 2501264..2502310 (-)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain SGAir0252
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2496264..2507310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CWR44_RS12315 (CWR44_12265)	-	2496807..2498054 (-)	1248	WP_011275381.1	aminopeptidase	-
CWR44_RS12320 (CWR44_12270)	-	2498068..2498277 (-)	210	WP_011275380.1	DUF1128 domain-containing protein	-
CWR44_RS12325 (CWR44_12275)	-	2498419..2498883 (+)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
CWR44_RS12330 (CWR44_12280)	-	2498889..2499173 (+)	285	WP_011275378.1	YtxH domain-containing protein	-
CWR44_RS12335 (CWR44_12285)	-	2499370..2500581 (+)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
CWR44_RS12340 (CWR44_12290)	vraR	2500645..2501274 (-)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
CWR44_RS12345 (CWR44_12295)	vraS	2501264..2502310 (-)	1047	WP_011275375.1	sensor histidine kinase	Regulator
CWR44_RS12350 (CWR44_12300)	liaF	2502307..2503008 (-)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
CWR44_RS12355 (CWR44_12305)	-	2503033..2503419 (-)	387	WP_011275373.1	hypothetical protein	-
CWR44_RS12360 (CWR44_12310)	-	2503632..2504644 (+)	1013	Protein_2398	HoxN/HupN/NixA family nickel/cobalt transporter	-
CWR44_RS12365 (CWR44_12315)	-	2504716..2505573 (+)	858	WP_011275370.1	SDR family oxidoreductase	-
CWR44_RS12370 (CWR44_12320)	map	2505698..2506450 (-)	753	WP_011275369.1	type I methionyl aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=257509 CWR44_RS12345 WP_011275375.1 2501264..2502310(-) (vraS) [Staphylococcus haemolyticus strain SGAir0252]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=257509 CWR44_RS12345 WP_011275375.1 2501264..2502310(-) (vraS) [Staphylococcus haemolyticus strain SGAir0252]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914