Detailed information NTG0256947

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: CVO91_RS11385
• Genome accession: NZ_CP024974
• Coordinates: 2243597..2246047 (-)
• Length: 816 a.a.
• NCBI ID: WP_100664932.1
• Uniprot ID: -
• Organism: Streptococcus suis strain CZ130302
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	2241912..2266822	2243597..2246047	within	0

Gene organization within MGE regions

Location: 2241912..2266822

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CVO91_RS11375 (CVO91_11375)	dusB	2241912..2242916 (+)	1005	WP_100664931.1	tRNA dihydrouridine synthase DusB	-
CVO91_RS11380 (CVO91_11380)	-	2243012..2243503 (-)	492	WP_002940137.1	adenylyltransferase/cytidyltransferase family protein	-
CVO91_RS11385 (CVO91_11385)	clpC	2243597..2246047 (-)	2451	WP_100664932.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
CVO91_RS11390 (CVO91_11390)	-	2246051..2246509 (-)	459	WP_002937810.1	CtsR family transcriptional regulator	-
CVO91_RS11395 (CVO91_11395)	-	2246780..2247118 (+)	339	WP_100664933.1	thioredoxin domain-containing protein	-
CVO91_RS11400 (CVO91_11400)	-	2247118..2247819 (+)	702	WP_100664934.1	GNAT family acetyltransferase	-
CVO91_RS11405 (CVO91_11405)	tsf	2248139..2249179 (-)	1041	WP_002940148.1	translation elongation factor Ts	-
CVO91_RS11410 (CVO91_11410)	rpsB	2249447..2250223 (-)	777	WP_002940151.1	30S ribosomal protein S2	-
CVO91_RS11415 (CVO91_11415)	-	2250467..2251924 (-)	1458	WP_002940153.1	arylsulfatase	-
CVO91_RS11420 (CVO91_11420)	-	2251945..2252760 (-)	816	WP_002940154.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
CVO91_RS11425 (CVO91_11425)	-	2252747..2253538 (-)	792	WP_002940155.1	PTS sugar transporter subunit IIC	-
CVO91_RS11430 (CVO91_11430)	-	2253739..2254710 (+)	972	WP_002940157.1	LacI family DNA-binding transcriptional regulator	-
CVO91_RS11435 (CVO91_11435)	-	2254953..2256071 (-)	1119	WP_002940159.1	radical SAM protein	-
CVO91_RS11445 (CVO91_11445)	-	2256999..2258120 (-)	1122	WP_029178298.1	IS110 family transposase	-
CVO91_RS11450 (CVO91_11450)	-	2258591..2259457 (-)	867	WP_002940248.1	formylglycine-generating enzyme family protein	-
CVO91_RS11455 (CVO91_11455)	-	2260526..2261308 (+)	783	WP_002940250.1	sulfite exporter TauE/SafE family protein	-
CVO91_RS11460 (CVO91_11460)	nusG	2261597..2262136 (-)	540	WP_002940254.1	transcription termination/antitermination protein NusG	-
CVO91_RS11465 (CVO91_11465)	secE	2262247..2262423 (-)	177	WP_002940255.1	preprotein translocase subunit SecE	-
CVO91_RS11470 (CVO91_11470)	rpmG	2262433..2262585 (-)	153	WP_002940258.1	50S ribosomal protein L33	-
CVO91_RS11475 (CVO91_11475)	pbp2a	2262619..2264832 (-)	2214	WP_002940262.1	penicillin-binding protein PBP2A	-
CVO91_RS11480 (CVO91_11480)	-	2264985..2265953 (+)	969	WP_002940264.1	NAD(P)/FAD-dependent oxidoreductase	-
CVO91_RS11485 (CVO91_11485)	-	2265956..2266822 (+)	867	WP_033875384.1	RluA family pseudouridine synthase	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90377.90 Da
• Isoelectric Point: 6.2908

>NTDB_id=256947 CVO91_RS11385 WP_100664932.1 2243597..2246047(-) (clpC) [Streptococcus suis strain CZ130302]
MKISTGLQRVFEDAQLVAQRYACDYLETWHVLLSFVINHDTVAGAVLAEYPISISDYEHATFVVTDKVYREELDSFRILP
SSKRLDETASFAKKIAEVVKAKELGTEHLFMAMLLDKRSTASQILDKVGFCFEDSDDKFRFLDLRKNLEARAGFTKEDLK
AIRSVMKGGKAKPTNMGQMMGMPPAPQSGGLEDYTRDLTALAREGKIEPVIGRDAEIARMIQILSRKTKNNPVLVGDAGV
GKTALALGLAQRVAAGDVPVSLAKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQTEYQKHIEKDAALVRRFAKVTIEEPTVEDSIAILTGLKGTFEKYHRVRIGQAAV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRVKGQAEETGLTSIDKALMDKKYKTVSKLLIKTKEDAEASQNYDLEV
TEEDVLETLSRLSGIPVAKLSQSDTKKYLNLEAELHKRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGVGK
TELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLL
QVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKVVF
HSLTETHMQDVVKVMVKPLLAVTAEKGITLKLQPSAFKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGDLATGST
LKVGVKGEELKFDVVK

Nucleotide

• Length: 2451 bp

>NTDB_id=256947 CVO91_RS11385 WP_100664932.1 2243597..2246047(-) (clpC) [Streptococcus suis strain CZ130302]
ATGAAAATTTCAACTGGTTTACAGCGGGTTTTTGAAGATGCCCAGTTAGTGGCCCAACGTTATGCCTGTGATTACTTGGA
AACCTGGCATGTTCTCTTGTCTTTCGTTATCAACCATGATACAGTCGCTGGCGCTGTTTTGGCAGAATATCCTATTTCAA
TTTCTGACTATGAACATGCAACTTTTGTTGTGACCGACAAGGTCTATCGTGAAGAGTTGGATAGTTTTCGTATTTTACCA
TCTTCTAAACGTTTGGATGAAACAGCTAGTTTTGCCAAGAAAATTGCAGAAGTCGTCAAGGCTAAGGAGTTGGGAACGGA
ACATTTGTTTATGGCTATGTTGTTGGACAAGCGGTCAACAGCTAGTCAGATTTTGGACAAGGTAGGTTTTTGTTTTGAAG
ACTCAGATGATAAGTTTCGTTTCTTGGATTTGCGTAAAAACTTGGAGGCACGTGCGGGATTTACCAAAGAGGACCTTAAA
GCTATCCGCAGTGTGATGAAGGGTGGCAAAGCCAAACCTACTAATATGGGACAGATGATGGGAATGCCCCCAGCACCTCA
AAGTGGTGGATTAGAAGACTACACTCGTGATTTGACAGCTTTGGCGCGTGAAGGGAAGATTGAACCTGTCATCGGTCGAG
ACGCTGAGATTGCACGGATGATCCAAATTCTATCACGTAAAACCAAGAACAACCCAGTTCTAGTTGGTGATGCTGGTGTC
GGAAAAACTGCGCTTGCTTTGGGTCTTGCTCAACGTGTTGCTGCAGGTGATGTCCCTGTCAGCTTGGCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAACGTTATCGCTGGAACTCGTTTCCGTGGTGATTTCGAAGAGCGGATGAATAATATCATCA
ACGACATCGAGGAAGATGGTCAGGTGATTCTCTTCATCGATGAGTTGCATACCATTATGGGTTCTGGCTCGGGGATTGAT
TCGACCTTGGATGCAGCCAATATCCTCAAACCAGCTCTTGCTCGTGGCACCCTCCGTACGGTCGGAGCGACGACTCAGAC
AGAGTACCAAAAGCATATTGAGAAAGACGCAGCCCTGGTTCGTCGTTTTGCCAAAGTGACCATTGAAGAGCCGACAGTGG
AAGATAGCATTGCCATTTTGACTGGTTTAAAAGGTACTTTTGAGAAATACCACAGGGTCCGTATTGGACAAGCAGCTGTA
GAGACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCAGCCATTGATTTGCTGGATGAAGC
CAGTGCAACGGTACAAAATCGAGTGAAAGGGCAGGCTGAGGAAACAGGACTGACGAGCATAGACAAGGCCTTGATGGATA
AAAAATATAAGACTGTCAGCAAGCTTTTGATTAAAACGAAAGAAGATGCCGAGGCTAGTCAAAACTATGACCTTGAAGTA
ACAGAAGAAGATGTTTTAGAAACACTTAGCCGCTTGTCAGGTATCCCAGTAGCCAAGCTTAGCCAATCAGATACTAAGAA
GTATCTGAATCTGGAAGCAGAATTGCACAAGCGTGTGATTGGGCAGGAAGAAGCTATTTCTGCAGTTAGCAGAGCTATTC
GCCGTAATCAGTCAGGGATTCGTACAGGTCGCAGACCGATTGGTTCATTCATGTTCTTGGGACCAACTGGTGTCGGCAAG
ACAGAGCTTGCTAAAGCCTTGGCAGAGGTTCTCTTTGATGATGAATCTGCTCTTATCCGTTTTGATATGTCTGAGTATAT
GGAGAAATTTGCGGCCAGCCGTCTCAATGGAGCGCCTCCAGGCTACGTGGGCTATGAAGAAGGTGGCGAATTGACAGAAA
AAGTTCGTAACAAACCTTATTCTGTTCTTCTTTTTGATGAGGTTGAAAAGGCTCATCCAGATATTTTCAATGTTCTCTTG
CAGGTCTTGGATGATGGTGTTCTGACGGACAGTAAGGGACGTAAGGTTGATTTCTCAAATACTATTATTATCATGACATC
AAACCTTGGAGCAACAGCCCTTCGTGATGATAAGACAGTTGGTTTTGGTGCCCTTGATTTATCTAAGGACCACAAGGAAG
TGGAGAAGCGCATTTTTGAGGAATTGAAAAAAGCCTATCGTCCAGAATTTATCAACCGTATTGACGAGAAAGTTGTCTTC
CATAGCCTAACGGAAACTCATATGCAGGATGTTGTCAAGGTCATGGTTAAACCTTTGTTGGCTGTAACAGCTGAGAAAGG
AATTACCCTTAAACTGCAACCGTCAGCCTTTAAGTTGTTAGCTAAACAAGGTTACGACCCAGAAATGGGAGCTCGTCCAC
TTCGTAGACTCTTGCAGACCAAATTGGAAGACCCATTAGCAGAAATGTTGCTCCGTGGTGACTTGGCTACTGGTTCGACC
TTGAAGGTTGGGGTCAAGGGTGAAGAGCTCAAGTTTGATGTGGTCAAATAG

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-803)

• ATPase family associated with various cellular activities (AAA) (AAA) (233-365)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (102-129)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-56)

• AAA lid domain (AAA_lid_9) (372-457)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	71.902	99.877	0.718
clpC	Streptococcus pneumoniae D39	71.902	99.877	0.718
clpC	Streptococcus pneumoniae TIGR4	71.902	99.877	0.718
clpC	Streptococcus mutans UA159	66.83	99.755	0.667
clpC	Streptococcus thermophilus LMD-9	63.962	100	0.657
clpC	Streptococcus thermophilus LMG 18311	64.38	100	0.656
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.222	100	0.504
clpC	Bacillus subtilis subsp. subtilis str. 168	43.353	100	0.444