Detailed information NTG0256936

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: CVO91_RS09390
• Genome accession: NZ_CP024974
• Coordinates: 1842071..1844299 (+)
• Length: 742 a.a.
• NCBI ID: WP_015646546.1
• Uniprot ID: A0A0M9FFN0
• Organism: Streptococcus suis strain CZ130302
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1837071..1849299

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CVO91_RS09365 (CVO91_09365)	-	1837499..1838663 (-)	1165	Protein_1761	IS110 family transposase	-
CVO91_RS09370 (CVO91_09370)	-	1838993..1839841 (-)	849	WP_100664899.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
CVO91_RS09375 (CVO91_09375)	-	1840075..1840809 (-)	735	WP_002943067.1	amino acid ABC transporter ATP-binding protein	-
CVO91_RS09380 (CVO91_09380)	-	1840802..1841491 (-)	690	WP_002938702.1	amino acid ABC transporter permease	-
CVO91_RS09385 (CVO91_09385)	-	1841617..1841847 (-)	231	WP_002938704.1	DUF1797 family protein	-
CVO91_RS09390 (CVO91_09390)	clpE	1842071..1844299 (+)	2229	WP_015646546.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
CVO91_RS09395 (CVO91_09395)	-	1844485..1844946 (+)	462	WP_002938708.1	NUDIX hydrolase	-
CVO91_RS09400 (CVO91_09400)	-	1845001..1845309 (+)	309	WP_002938710.1	DUF1827 family protein	-
CVO91_RS09405 (CVO91_09405)	ileS	1845493..1848282 (-)	2790	WP_100664900.1	isoleucine--tRNA ligase	-
CVO91_RS09410 (CVO91_09410)	-	1848293..1848733 (-)	441	WP_100664901.1	GNAT family N-acetyltransferase	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 82596.95 Da
• Isoelectric Point: 5.2782

>NTDB_id=256936 CVO91_RS09390 WP_015646546.1 1842071..1844299(+) (clpE) [Streptococcus suis strain CZ130302]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGGHNGRGGQTPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGISLHVTDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide

• Length: 2229 bp

>NTDB_id=256936 CVO91_RS09390 WP_015646546.1 1842071..1844299(+) (clpE) [Streptococcus suis strain CZ130302]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACACCAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTAATAATGCCATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAATATGGATCCCTTTAGTGAATTCTTCAATCACCTAGGTGGCTACCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCCACTCAAGCCGGTGGGCATAATGGACGTGGTGGACAGACCCCTCCTCCGCAACAACCCCAACAACC
AAATGGGCTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAAATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAACCCTGTTCTTATCGGTGAGCCTGGTGTA
GGTAAAACAGCGGTTGTTGAAGGTTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAGAAATTACGAGACAAGGAAGT
CATTCGTCTGGATGTTGTCAGCCTCGTACAAGGAACAGGTATCCGCGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATCATTCTTTTTATTGATGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAGCTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACTATTCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCCGCAGTACTGTCCAACCGCTACATTCAAGACCGTTTCCTACCAGACAAGGCTATTGACCTTCTGGATGAAGCTGG
TTCAAAAATGAATTTGACCCTCAACTTTATTGATCCAAAGGAAATTGACCAACGCCTGATTGATGCCGAAAATCGTAAGG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCAGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAGGAAGATATTCCACTCATTACTGAAAAAGAAATTGAGGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTAAACCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAACCGTGTCGGTCTCGGTGCCCCAAACCGTCCAATCGGTTCC
TTCCTATTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAACAATTAGCTATCGAACTCTTCGGTTCGGCTGA
CAGCATGATCCGCTTCGACATGTCCGAATACATGGAAAAACACGCTGTAGCTAAACTCGTCGGAGCTCCTCCAGGCTATG
TAGGCTATGAGGAGGCTGGACAATTGACTGAAAAAGTCCGCCGCAATCCTTACTCTCTCATCCTCTTGGATGAGGTAGAA
AAAGCCCACCCTGATGTCATGCACATGTTCCTTCAGGTCTTAGACGATGGGCGTCTGACAGATGGACAAGGGCGGACTGT
CAGCTTCAAAGATACTATCATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGT
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCAGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACGATCCAAAGATGG
GAGCTCGTCCACTACGCAGAACCATCCAAGATCAGATTGAAGATGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (476-639)

• AAA lid domain (AAA_lid_9) (291-389)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (647-721)

• ATPase family associated with various cellular activities (AAA) (AAA) (153-272)

3D structure

• AlphaFold DB: A0A0M9FFN0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	82.361	100	0.837
clpE	Streptococcus pneumoniae D39	82.361	100	0.837
clpE	Streptococcus pneumoniae R6	82.361	100	0.837
clpE	Streptococcus pneumoniae TIGR4	82.361	100	0.837
clpE	Streptococcus mutans UA159	82.377	100	0.832
clpC	Lactococcus lactis subsp. cremoris KW2	77.655	97.709	0.759
clpC	Bacillus subtilis subsp. subtilis str. 168	52.462	87.601	0.46
clpC	Streptococcus mutans UA159	48.558	84.097	0.408
clpC	Streptococcus thermophilus LMD-9	48.248	84.636	0.408
clpC	Streptococcus thermophilus LMG 18311	47.93	84.636	0.406
clpC	Streptococcus pneumoniae TIGR4	47.84	84.232	0.403
clpC	Streptococcus pneumoniae Rx1	47.84	84.232	0.403
clpC	Streptococcus pneumoniae D39	47.84	84.232	0.403
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.815	84.636	0.396