Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   CV724_RS03385 Genome accession   NZ_CP024952
Coordinates   682164..683948 (-) Length   594 a.a.
NCBI ID   WP_145726965.1    Uniprot ID   -
Organism   Helicobacter pylori strain B125A     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 677164..688948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CV724_RS08435 - 677188..677377 (-) 190 Protein_622 hypothetical protein -
  CV724_RS03355 (CV724_03360) - 677531..677779 (+) 249 WP_000790555.1 RNA-binding protein -
  CV724_RS03360 (CV724_03365) - 678013..678834 (-) 822 WP_145726963.1 glycosyltransferase family 25 protein -
  CV724_RS03365 (CV724_03370) trxB 679193..680128 (-) 936 WP_108263842.1 thioredoxin-disulfide reductase -
  CV724_RS03370 (CV724_03375) trxA 680134..680454 (-) 321 WP_000020199.1 thioredoxin -
  CV724_RS03375 (CV724_03380) - 680543..680887 (-) 345 WP_001211688.1 YraN family protein -
  CV724_RS03380 (CV724_03385) - 680888..682153 (-) 1266 WP_145726964.1 homoserine dehydrogenase -
  CV724_RS03385 (CV724_03390) uvrC 682164..683948 (-) 1785 WP_145726965.1 excinuclease ABC subunit UvrC Machinery gene
  CV724_RS03390 (CV724_03395) - 683949..684410 (-) 462 WP_000437184.1 hypothetical protein -
  CV724_RS03395 (CV724_03400) - 684402..684581 (+) 180 WP_000468793.1 hypothetical protein -
  CV724_RS03400 (CV724_03405) - 684584..685234 (-) 651 WP_000659429.1 ATP-binding cassette domain-containing protein -
  CV724_RS03405 (CV724_03410) - 685236..686897 (-) 1662 WP_145726966.1 glycine betaine ABC transporter substrate-binding protein -
  CV724_RS03410 (CV724_03415) - 686966..687403 (-) 438 WP_001875641.1 hypothetical protein -
  CV724_RS03415 (CV724_03420) motB 687409..688182 (-) 774 WP_001085345.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68688.96 Da        Isoelectric Point: 9.6704

>NTDB_id=256657 CV724_RS03385 WP_145726965.1 682164..683948(-) (uvrC) [Helicobacter pylori strain B125A]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNPRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSDEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=256657 CV724_RS03385 WP_145726965.1 682164..683948(-) (uvrC) [Helicobacter pylori strain B125A]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAAGCGAAAAACTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAACAATGAAATCACGCCCA
ATCCTCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAACAATTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGACATTTTTGCTTTTTATGGTGGGAACAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATACCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAATGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAAACTCTTACCGGCG
CTACCATTTGAAAGGTTCTGATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

98.653

100

0.987

Multiple sequence alignment