Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   CV725_RS04870 Genome accession   NZ_CP024951
Coordinates   968728..970512 (-) Length   594 a.a.
NCBI ID   WP_000774326.1    Uniprot ID   -
Organism   Helicobacter pylori B128     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 963728..975512
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CV725_RS04840 (CV725_04840) - 964185..964433 (+) 249 WP_000790564.1 RNA-binding protein -
  CV725_RS04845 (CV725_04845) - 964653..965474 (-) 822 WP_001263408.1 glycosyltransferase family 25 protein -
  CV725_RS04850 (CV725_04850) trxB 965757..966692 (-) 936 WP_000564427.1 thioredoxin-disulfide reductase -
  CV725_RS04855 (CV725_04855) trxA 966698..967018 (-) 321 WP_000020199.1 thioredoxin -
  CV725_RS04860 (CV725_04860) - 967107..967451 (-) 345 WP_001211718.1 YraN family protein -
  CV725_RS04865 (CV725_04865) - 967452..968717 (-) 1266 WP_000746737.1 homoserine dehydrogenase -
  CV725_RS04870 (CV725_04870) uvrC 968728..970512 (-) 1785 WP_000774326.1 excinuclease ABC subunit UvrC Machinery gene
  CV725_RS04875 (CV725_04875) - 970513..970974 (-) 462 WP_000437213.1 hypothetical protein -
  CV725_RS04880 (CV725_04880) - 970966..971145 (+) 180 WP_000468791.1 hypothetical protein -
  CV725_RS04885 (CV725_04885) - 971148..971798 (-) 651 WP_000659414.1 ATP-binding cassette domain-containing protein -
  CV725_RS04890 (CV725_04890) - 971801..973462 (-) 1662 WP_001133315.1 glycine betaine ABC transporter substrate-binding protein -
  CV725_RS04895 (CV725_04895) - 973531..973968 (-) 438 WP_001039460.1 hypothetical protein -
  CV725_RS04900 (CV725_04900) motB 973974..974747 (-) 774 WP_001085351.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68680.98 Da        Isoelectric Point: 9.6703

>NTDB_id=256639 CV725_RS04870 WP_000774326.1 968728..970512(-) (uvrC) [Helicobacter pylori B128]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYSKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
ACSNEALKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKISNEDLILEEARSLFKLECMPYRVEIFDT
SHHSSSQCVGGMVVYENNAFQKDSYRRYHLKGSDEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRAKGGAKDIIHTISNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=256639 CV725_RS04870 WP_000774326.1 968728..970512(-) (uvrC) [Helicobacter pylori B128]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAAGCGAAAAACTTAAAAAAGCGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ACCATCGCACAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAACAATTTGCGTTTTGAAGAAGCCCTAATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAAGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCTGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGATTTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAATCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAATGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCTAGCAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAACGCATTTCAAAAAGATTCTTATCGGCG
CTACCATTTGAAAGGCTCTGATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTACCGCGCTAAAGGAGGCGCTAAAGACATTAT
CCATACGATTAGTAATACTTTTAAATTACTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.811

100

0.978

Multiple sequence alignment