Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   CV726_RS03380 Genome accession   NZ_CP024950
Coordinates   681198..682982 (-) Length   594 a.a.
NCBI ID   WP_145940205.1    Uniprot ID   -
Organism   Helicobacter pylori strain B130A     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 676198..687982
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CV726_RS03350 (CV726_03355) - 676582..676830 (+) 249 WP_000790557.1 RNA-binding protein -
  CV726_RS03355 (CV726_03360) - 677034..677855 (-) 822 WP_145940201.1 glycosyltransferase family 25 protein -
  CV726_RS03360 (CV726_03365) trxB 678228..679163 (-) 936 WP_145940202.1 thioredoxin-disulfide reductase -
  CV726_RS03365 (CV726_03370) trxA 679169..679489 (-) 321 WP_000020199.1 thioredoxin -
  CV726_RS03370 (CV726_03375) - 679578..679922 (-) 345 WP_145940203.1 YraN family protein -
  CV726_RS03375 (CV726_03380) - 679922..681187 (-) 1266 WP_145940204.1 homoserine dehydrogenase -
  CV726_RS03380 (CV726_03385) uvrC 681198..682982 (-) 1785 WP_145940205.1 excinuclease ABC subunit UvrC Machinery gene
  CV726_RS03385 (CV726_03390) - 682983..683444 (-) 462 WP_000437184.1 hypothetical protein -
  CV726_RS03390 (CV726_03395) - 683436..683615 (+) 180 WP_000468794.1 hypothetical protein -
  CV726_RS03395 (CV726_03400) - 683612..684268 (-) 657 WP_145940206.1 ABC transporter ATP-binding protein -
  CV726_RS03400 (CV726_03405) - 684271..685932 (-) 1662 WP_145940758.1 ABC transporter permease/substrate-binding protein -
  CV726_RS03405 (CV726_03410) - 686001..686438 (-) 438 WP_001875641.1 hypothetical protein -
  CV726_RS03410 (CV726_03415) motB 686444..687217 (-) 774 WP_001085345.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68626.78 Da        Isoelectric Point: 9.7157

>NTDB_id=256624 CV726_RS03380 WP_145940205.1 681198..682982(-) (uvrC) [Helicobacter pylori strain B130A]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNSRVSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMDRLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGTSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAIKNAQEIFSQEKTSSEDLILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLRKRK

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=256624 CV726_RS03380 WP_145940205.1 681198..682982(-) (uvrC) [Helicobacter pylori strain B130A]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCTA
ATTCTCGCGTAAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCTACTGATTTCCCTATCCCTTTAATCACACGAAAAATCTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACAAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAGTTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGATCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTCATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCACAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCTGAACAGATCTTATTGAAC
GCTTGTTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATAAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
GTGAAGATCTGATTTTAGAAGAAGCGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGAGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGTAGCGGGAGT
TTTGTAGAAGTGATTGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTACTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAGAAAACGAAAATAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.133

99.832

0.97

Multiple sequence alignment