Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   CV727_RS04960 Genome accession   NZ_CP024949
Coordinates   1027965..1029749 (+) Length   594 a.a.
NCBI ID   WP_145820721.1    Uniprot ID   -
Organism   Helicobacter pylori strain B136A     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1022965..1034749
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CV727_RS04930 (CV727_04935) motB 1023729..1024502 (+) 774 WP_079300656.1 flagellar motor protein MotB -
  CV727_RS04935 (CV727_04940) - 1024508..1024945 (+) 438 WP_001885597.1 hypothetical protein -
  CV727_RS04940 (CV727_04945) - 1025014..1026675 (+) 1662 WP_145820718.1 ABC transporter permease/substrate-binding protein -
  CV727_RS04945 (CV727_04950) - 1026679..1027320 (+) 642 WP_145820719.1 ATP-binding cassette domain-containing protein -
  CV727_RS04950 (CV727_04955) - 1027332..1027511 (-) 180 WP_001847249.1 hypothetical protein -
  CV727_RS04955 (CV727_04960) - 1027503..1027964 (+) 462 WP_145820720.1 hypothetical protein -
  CV727_RS04960 (CV727_04965) uvrC 1027965..1029749 (+) 1785 WP_145820721.1 excinuclease ABC subunit UvrC Machinery gene
  CV727_RS04965 (CV727_04970) - 1029760..1031025 (+) 1266 WP_145820723.1 homoserine dehydrogenase -
  CV727_RS04970 (CV727_04975) - 1031026..1031370 (+) 345 WP_145820724.1 YraN family protein -
  CV727_RS04975 (CV727_04980) trxA 1031459..1031779 (+) 321 WP_000020199.1 thioredoxin -
  CV727_RS04980 (CV727_04985) trxB 1031785..1032720 (+) 936 WP_120910663.1 thioredoxin-disulfide reductase -
  CV727_RS04985 (CV727_04990) - 1033077..1033898 (+) 822 WP_145820725.1 glycosyltransferase family 25 protein -
  CV727_RS04990 (CV727_04995) - 1034108..1034356 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68654.85 Da        Isoelectric Point: 9.6283

>NTDB_id=256597 CV727_RS04960 WP_145820721.1 1027965..1029749(+) (uvrC) [Helicobacter pylori strain B136A]
MADLLSSLKNLSSSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNPRASLRVQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSIDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQEFISHQYSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=256597 CV727_RS04960 WP_145820721.1 1027965..1029749(+) (uvrC) [Helicobacter pylori strain B136A]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAGTAGTAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGAATCAAAAGCTACTTTTCTATCCGTAATAATGAAATCACGCCCA
ATCCTCGCGCAAGCTTACGCGTCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTGATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCTATTGATTTCCCTATCCCTTTAATCACGAGAAAAATCTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGTGGGAACAATAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAGGCAATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAGATCTTATTGAGC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAATATCCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAAACTCTTACCGGCG
CTACCATCTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.138

100

0.971

Multiple sequence alignment