Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   CV728_RS04720 Genome accession   NZ_CP024948
Coordinates   970160..971944 (+) Length   594 a.a.
NCBI ID   WP_145817404.1    Uniprot ID   -
Organism   Helicobacter pylori strain B140     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 965160..976944
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CV728_RS04690 (CV728_04705) motB 965924..966697 (+) 774 WP_078251028.1 flagellar motor protein MotB -
  CV728_RS04695 (CV728_04710) - 966703..967140 (+) 438 WP_001885597.1 hypothetical protein -
  CV728_RS04700 (CV728_04715) - 967209..968870 (+) 1662 WP_145817398.1 ABC transporter permease/substrate-binding protein -
  CV728_RS04705 (CV728_04720) - 968874..969515 (+) 642 WP_145817400.1 ATP-binding cassette domain-containing protein -
  CV728_RS04710 (CV728_04725) - 969527..969706 (-) 180 WP_033616086.1 hypothetical protein -
  CV728_RS04715 (CV728_04730) - 969698..970159 (+) 462 WP_145817402.1 hypothetical protein -
  CV728_RS04720 (CV728_04735) uvrC 970160..971944 (+) 1785 WP_145817404.1 excinuclease ABC subunit UvrC Machinery gene
  CV728_RS04725 (CV728_04740) - 971955..973220 (+) 1266 WP_145817406.1 homoserine dehydrogenase -
  CV728_RS04730 (CV728_04745) - 973220..973564 (+) 345 WP_033588482.1 YraN family protein -
  CV728_RS04735 (CV728_04750) trxA 973653..973973 (+) 321 WP_000020199.1 thioredoxin -
  CV728_RS04740 (CV728_04755) trxB 973978..974913 (+) 936 WP_120899955.1 thioredoxin-disulfide reductase -
  CV728_RS04745 (CV728_04760) - 975271..976092 (+) 822 WP_145817408.1 glycosyltransferase family 25 protein -
  CV728_RS04750 (CV728_04765) - 976307..976555 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68557.63 Da        Isoelectric Point: 9.6316

>NTDB_id=256572 CV728_RS04720 WP_145817404.1 970160..971944(+) (uvrC) [Helicobacter pylori strain B140]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMECLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQDFISHQYSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDPILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFTKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASDQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=256572 CV728_RS04720 WP_145817404.1 970160..971944(+) (uvrC) [Helicobacter pylori strain B140]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ATCATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAATGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCCTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGTGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCTAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGACATTTTTGCTTTTTATGGTGGGAACAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CCGATGAAGCGATGAAACAAGCCATTATTAACCATTACCAATCGCATTTACCTTTGATGCCTGAACAGATCTTATTGAGT
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCTCATCAATACTCTAAAAAAATCGCTCTTAATATCCC
TAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCCGATTTTAGAAGAAGCGCGATCGCTTTTTAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTACTAAAGAGC
CGCCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCACAATTAAACATCGCTTTAGAAATCTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCTAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGATCAGGAAAAAAA
CGCCGTTTTGAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.133

99.832

0.97

Multiple sequence alignment