Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   CV729_RS05155 Genome accession   NZ_CP024947
Coordinates   1053952..1055736 (+) Length   594 a.a.
NCBI ID   WP_145732761.1    Uniprot ID   -
Organism   Helicobacter pylori strain J182     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1048952..1060736
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CV729_RS05120 (CV729_05125) - 1049006..1049350 (+) 345 Protein_984 osmoprotection protein -
  CV729_RS05125 (CV729_05130) - 1049367..1049939 (-) 573 WP_145732746.1 Hpy99I family type II restriction endonuclease -
  CV729_RS05130 (CV729_05135) - 1049933..1050751 (-) 819 WP_145732749.1 site-specific DNA-methyltransferase -
  CV729_RS05135 (CV729_05140) - 1051002..1052663 (+) 1662 WP_145732753.1 ABC transporter permease/substrate-binding protein -
  CV729_RS05140 (CV729_05145) - 1052666..1053307 (+) 642 WP_145732756.1 ATP-binding cassette domain-containing protein -
  CV729_RS05145 (CV729_05150) - 1053319..1053498 (-) 180 WP_000468791.1 hypothetical protein -
  CV729_RS05150 (CV729_05155) - 1053490..1053951 (+) 462 WP_145732758.1 hypothetical protein -
  CV729_RS05155 (CV729_05160) uvrC 1053952..1055736 (+) 1785 WP_145732761.1 excinuclease ABC subunit UvrC Machinery gene
  CV729_RS05160 (CV729_05165) - 1055747..1057012 (+) 1266 WP_145732766.1 homoserine dehydrogenase -
  CV729_RS05165 (CV729_05170) - 1057012..1057356 (+) 345 WP_001211672.1 YraN family protein -
  CV729_RS05170 (CV729_05175) trxA 1057445..1057765 (+) 321 WP_000020199.1 thioredoxin -
  CV729_RS05175 (CV729_05180) trxB 1057771..1058706 (+) 936 WP_000564414.1 thioredoxin-disulfide reductase -
  CV729_RS05180 (CV729_05185) - 1059080..1059901 (+) 822 WP_145732770.1 glycosyltransferase family 25 protein -
  CV729_RS05185 (CV729_05190) - 1060104..1060352 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68621.85 Da        Isoelectric Point: 9.6704

>NTDB_id=256564 CV729_RS05155 WP_145732761.1 1053952..1055736(+) (uvrC) [Helicobacter pylori strain J182]
MADLLSSLKNLPHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRVSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACIFYQIERCKAPCENKITKEEYSKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGANNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
ACSSEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSDEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRAKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=256564 CV729_RS05155 WP_145732761.1 1053952..1055736(+) (uvrC) [Helicobacter pylori strain J182]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAACAATGAAATCACGCCCA
ATCATCGCGTAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCCTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGTGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATTTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAGCAATTTGCGTTTTGAAGAAGCCCTCATTTACAGGGACAGGATTGCAAAGATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGACATTTTTGCTTTTTATGGCGCAAACAATAAAGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAGATTTTATTGAAC
GCTTGCTCTAGTGAAGCGCTTAAAGAATTGCAAGAATTTATCTCCCACCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAGGAAAAAACCTCTA
ATGAGGATCTGATTTTAGAAGAAGCGCGATCGCTTTTCAAATTAGAATGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCTAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTCCAAAAAAACTCTTATCGGCG
CTACCATTTGAAAGGCTCTGATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCGCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGTGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

98.148

100

0.981

Multiple sequence alignment