Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DG474_RS08875 Genome accession   NZ_CP029257
Coordinates   1847024..1848973 (-) Length   649 a.a.
NCBI ID   WP_255778148.1    Uniprot ID   -
Organism   Streptococcus oralis strain CCUG 53468     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1842024..1853973
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS08845 (DG474_08990) - 1842305..1843339 (+) 1035 WP_255778141.1 S66 peptidase family protein -
  DG474_RS08850 (DG474_08995) - 1843445..1843708 (+) 264 WP_000166112.1 SemiSWEET family transporter -
  DG474_RS08855 (DG474_09000) - 1843788..1844354 (-) 567 WP_000166572.1 DNA-3-methyladenine glycosylase I -
  DG474_RS08860 (DG474_09005) ruvA 1844364..1844957 (-) 594 WP_000273410.1 Holliday junction branch migration protein RuvA Machinery gene
  DG474_RS08865 (DG474_09010) - 1844970..1846202 (-) 1233 WP_255778146.1 MFS transporter -
  DG474_RS08870 (DG474_09015) - 1846375..1846872 (+) 498 WP_247942982.1 helix-turn-helix domain-containing protein -
  DG474_RS08875 (DG474_09020) hexB 1847024..1848973 (-) 1950 WP_255778148.1 DNA mismatch repair endonuclease MutL Machinery gene
  DG474_RS08880 (DG474_09025) - 1849182..1849622 (+) 441 WP_255778149.1 LytTR family DNA-binding domain-containing protein -
  DG474_RS08885 (DG474_09030) - 1849619..1850077 (+) 459 WP_255778150.1 DUF3021 domain-containing protein -
  DG474_RS08890 (DG474_09035) hexA 1850119..1852653 (-) 2535 WP_255778151.1 DNA mismatch repair protein MutS Machinery gene
  DG474_RS08895 (DG474_09040) argR 1852704..1853150 (-) 447 WP_255778152.1 arginine repressor -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73448.86 Da        Isoelectric Point: 5.6136

>NTDB_id=252568 DG474_RS08875 WP_255778148.1 1847024..1848973(-) (hexB) [Streptococcus oralis strain CCUG 53468]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDAGSNQIIIEIEESGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLASAKKMIAIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKERELMALVSE
AISNSLKEQALIPDALENLAKSTVRNRQKVEQTILPLKENTLYYEKTELSKPSQAEVADHQVELTEERQDLTLFAKETLD
QLTKPAKLHFAERKPASYDQLDHPELDLASLDKAYDKLEREESSSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMHLLEEVGVFLAEYGENQFILREHPIWMTEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=252568 DG474_RS08875 WP_255778148.1 1847024..1848973(-) (hexB) [Streptococcus oralis strain CCUG 53468]
ATGTCTCATATTATTGAATTGCCAGAAGTGTTGGCAAACCAGATCGCGGCAGGAGAGGTCATTGAACGTCCTGCCAGTGT
GGTTAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCTAATCAGATTATCATTGAGATCGAGGAATCCGGTCTCAAGA
AAATTCAAATCACAGATAATGGTCATGGAATTGCCCACGATGAGGTGGAGTTGGCCTTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCCTGCCCTCTATCGCGTCTGTCAG
TGTTTTGACTTTGTTGACGGCGGTGGATGGTGCGAGTCATGGGACCAAGCTCGTTGCGCGTGGGGGAGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGGACCAAAGTTTGTGTGGAGGACCTCTTTTTCAACACACCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGCTGTCTCATATCATTGATATTGTCAACCGTCTGGGATTGGCTCATCCTGAGATTTCTTT
TAGTTTAATCAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAACTACGCCAAGCCATCGCAGGGATTTACG
GTTTAGCAAGCGCTAAAAAGATGATTGCTATTGAAAACTCTGACTTAGATTTCGAAATTTCAGGTTTTGTGTCCTTACCT
GAGTTGACTCGTGCAAACCGCAACTATATCAGTCTCTTTATCAATGGCCGTTATATCAAAAACTTCCTGCTCAACCGTGC
TATTTTAGATGGTTACGGCAGCAAGCTCATGGTGGGGCGTTTCCCACTGGCTGTCATTCACATCCATATTGATCCTTATC
TGGCTGATGTCAATGTGCATCCAACCAAGCAAGAAGTGCGGATTTCTAAGGAAAGAGAACTGATGGCGCTGGTTTCAGAA
GCTATTTCAAATAGTCTCAAGGAACAAGCCTTGATTCCTGATGCTTTAGAAAATCTTGCCAAGTCGACCGTGCGCAATCG
TCAAAAGGTAGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTTTACTATGAAAAAACAGAACTCTCAAAACCCAGTC
AAGCTGAGGTGGCTGATCATCAGGTTGAATTAACTGAGGAAAGACAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CAGTTGACCAAGCCTGCAAAACTGCATTTTGCAGAAAGAAAACCAGCTAGCTATGACCAATTAGACCATCCAGAGTTAGA
CTTAGCCAGTCTTGATAAGGCTTATGACAAGCTGGAGAGAGAAGAATCATCCAGCTTTCCAGAGTTGGAGTTTTTCGGAC
AAATGCATGGGACCTATCTCTTTGCTCAAGGTAGAGATGGGCTTTACATCATAGATCAGCATGCGGCACAGGAACGGGTC
AAATACGAGGAATACCGAGAGAGCATTGGCAATGTTGACCAGAGTCAGCAACAACTCCTAGTGCCCTACATCTTTGAATT
CCCAGCGGATGATGCCCTTCGTCTTAAAGAAAGAATGCATCTTTTGGAGGAAGTGGGCGTCTTTCTAGCAGAGTATGGAG
AAAATCAATTCATCCTGCGTGAACATCCCATCTGGATGACCGAAGAGGAAATCGAATCTGGTATCTATGAAATGTGCGAC
ATGCTCCTCTTGACTAAAGAAGTTTCGATTAAGAAATACCGAGCAGAGTTGGCCATTATGATGTCCTGCAAGCGGTCTAT
CAAGGCCAACCATCGTATCGATGACCACTCGGCTAGACAACTCCTCTACCAACTCTCTCAATGCGACAACCCATATAACT
GTCCTCATGGACGTCCTGTTTTGGTGCATTTCACCAAGTCAGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGCCTCCGAGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

96.302

100

0.963

Multiple sequence alignment