Detailed information NTG0025165

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAB_RS09865
• Genome accession: NC_007622
• Coordinates: 1951483..1952526 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus RF122
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1946483..1957526

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAB_RS09835 (SAB1811c)	-	1946904..1948160 (-)	1257	WP_078062667.1	aminopeptidase	-
SAB_RS09840 (SAB1812c)	-	1948163..1948363 (-)	201	WP_011382336.1	DUF1128 family protein	-
SAB_RS09845 (SAB1813)	-	1948510..1948974 (+)	465	WP_000228664.1	low molecular weight protein-tyrosine-phosphatase	-
SAB_RS09850 (SAB1814)	-	1948981..1949256 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAB_RS09855 (SAB1815)	-	1949534..1950751 (+)	1218	WP_000037066.1	YihY/virulence factor BrkB family protein	-
SAB_RS09860 (SAB1816c)	vraR	1950864..1951493 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SAB_RS09865 (SAB1817c)	vraS	1951483..1952526 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAB_RS09870 (SAB1818c)	liaF	1952523..1953224 (-)	702	WP_000149062.1	cell wall-active antibiotics response protein LiaF	-
SAB_RS09875 (SAB1819c)	-	1953239..1953625 (-)	387	WP_001110179.1	hypothetical protein	-
SAB_RS09880 (SAB1820c)	map	1953842..1954600 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAB_RS09885 (SAB1821)	-	1955012..1955998 (+)	987	WP_000999713.1	FUSC family protein	-
SAB_RS09890 (SAB1822c)	-	1956428..1956841 (-)	414	WP_011382337.1	hypothetical protein	-
SAB_RS09895	-	1956870..1956980 (-)	111	WP_042852778.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=25165 SAB_RS09865 WP_001017131.1 1951483..1952526(-) (vraS) [Staphylococcus aureus RF122]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=25165 SAB_RS09865 WP_001017131.1 1951483..1952526(-) (vraS) [Staphylococcus aureus RF122]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTGTTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1