Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | CRD75_RS05810 | Genome accession | NZ_CP023769 |
| Coordinates | 1135572..1137377 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain HarveyGAS | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1115321..1162376 | 1135572..1137377 | within | 0 |
Gene organization within MGE regions
Location: 1115321..1162376
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CRD75_RS05725 (CRD75_05725) | - | 1115359..1116633 (-) | 1275 | WP_011284930.1 | polysaccharide deacetylase family protein | - |
| CRD75_RS05730 (CRD75_05730) | - | 1116728..1118155 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| CRD75_RS05735 (CRD75_05735) | ptsP | 1118340..1120073 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| CRD75_RS05740 (CRD75_05740) | - | 1120078..1120341 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| CRD75_RS05745 (CRD75_05745) | - | 1120734..1120952 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| CRD75_RS05750 (CRD75_05750) | nrdE | 1120972..1123131 (+) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| CRD75_RS05755 (CRD75_05755) | nrdF | 1123464..1124423 (+) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| CRD75_RS05760 (CRD75_05760) | - | 1124398..1125711 (+) | 1314 | WP_011284932.1 | chloride channel protein | - |
| CRD75_RS05765 (CRD75_05765) | - | 1125807..1126957 (+) | 1151 | Protein_1074 | IS3 family transposase | - |
| CRD75_RS05775 (CRD75_05775) | - | 1127056..1127751 (-) | 696 | WP_002989227.1 | type II CAAX endopeptidase family protein | - |
| CRD75_RS05780 (CRD75_05780) | - | 1127770..1128531 (-) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| CRD75_RS05785 (CRD75_05785) | - | 1128528..1128743 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| CRD75_RS05790 (CRD75_05790) | alaS | 1129104..1131722 (-) | 2619 | WP_011284933.1 | alanine--tRNA ligase | - |
| CRD75_RS05795 (CRD75_05795) | prsA | 1132109..1133164 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| CRD75_RS05800 (CRD75_05800) | - | 1133227..1133934 (-) | 708 | WP_011284934.1 | O-methyltransferase | - |
| CRD75_RS05805 (CRD75_05805) | - | 1134000..1135196 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| CRD75_RS05810 (CRD75_05810) | pepF | 1135572..1137377 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| CRD75_RS05815 (CRD75_05815) | - | 1137390..1138352 (-) | 963 | WP_002995771.1 | competence protein CoiA | - |
| CRD75_RS05820 (CRD75_05820) | - | 1138647..1139363 (-) | 717 | WP_002989197.1 | pseudouridine synthase | - |
| CRD75_RS05825 (CRD75_05825) | nagB | 1139482..1140186 (-) | 705 | WP_021340997.1 | glucosamine-6-phosphate deaminase | - |
| CRD75_RS05830 (CRD75_05830) | queA | 1140388..1141416 (+) | 1029 | WP_011284937.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| CRD75_RS05835 (CRD75_05835) | - | 1141423..1142643 (+) | 1221 | WP_002989189.1 | DUF3114 domain-containing protein | - |
| CRD75_RS05840 (CRD75_05840) | - | 1142757..1143347 (-) | 591 | WP_002989185.1 | serine hydrolase | - |
| CRD75_RS05845 (CRD75_05845) | - | 1143344..1143592 (-) | 249 | WP_002989183.1 | serine hydrolase | - |
| CRD75_RS05850 (CRD75_05850) | - | 1143648..1143803 (-) | 156 | WP_002989180.1 | hypothetical protein | - |
| CRD75_RS05855 (CRD75_05855) | sodA | 1143970..1144575 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| CRD75_RS05860 (CRD75_05860) | holA | 1144672..1145712 (-) | 1041 | WP_002989176.1 | DNA polymerase III subunit delta | - |
| CRD75_RS05865 (CRD75_05865) | - | 1145783..1148025 (-) | 2243 | Protein_1093 | DNA internalization-related competence protein ComEC/Rec2 | - |
| CRD75_RS05870 (CRD75_05870) | - | 1148006..1148668 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| CRD75_RS05875 (CRD75_05875) | - | 1148868..1149608 (-) | 741 | WP_021340996.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| CRD75_RS05880 (CRD75_05880) | - | 1149726..1150502 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| CRD75_RS05885 (CRD75_05885) | - | 1150492..1150770 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| CRD75_RS05890 (CRD75_05890) | - | 1150794..1152794 (-) | 2001 | WP_011284942.1 | potassium transporter Kup | - |
| CRD75_RS05895 (CRD75_05895) | - | 1152921..1154540 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| CRD75_RS05900 (CRD75_05900) | - | 1154847..1156391 (-) | 1545 | WP_011284943.1 | peptide chain release factor 3 | - |
| CRD75_RS05910 (CRD75_05910) | - | 1156639..1157334 (-) | 696 | WP_011017956.1 | TIGR02206 family membrane protein | - |
| CRD75_RS05915 (CRD75_05915) | murF | 1157414..1158805 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| CRD75_RS05920 (CRD75_05920) | - | 1159004..1160050 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| CRD75_RS05925 (CRD75_05925) | recR | 1160151..1160747 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| CRD75_RS09795 (CRD75_05930) | - | 1160794..1160985 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| CRD75_RS05935 (CRD75_05935) | - | 1161545..1162324 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=249840 CRD75_RS05810 WP_011054652.1 1135572..1137377(-) (pepF) [Streptococcus pyogenes strain HarveyGAS]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=249840 CRD75_RS05810 WP_011054652.1 1135572..1137377(-) (pepF) [Streptococcus pyogenes strain HarveyGAS]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |