Detailed information NTG0248239

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CPG32_RS02600
• Genome accession: NZ_CP023539
• Coordinates: 514103..515146 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain FDAARGOS_377
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 509103..520146

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CPG32_RS02575 (CPG32_02575)	-	509393..510754 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
CPG32_RS02580 (CPG32_02580)	-	510888..511868 (-)	981	WP_002492696.1	aromatic acid exporter family protein	-
CPG32_RS02585 (CPG32_02585)	map	512113..512868 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
CPG32_RS02590 (CPG32_02590)	-	512994..513380 (+)	387	WP_002477960.1	hypothetical protein	-
CPG32_RS02595 (CPG32_02595)	liaF	513405..514106 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
CPG32_RS02600 (CPG32_02600)	vraS	514103..515146 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
CPG32_RS02605 (CPG32_02605)	vraR	515136..515765 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
CPG32_RS02610 (CPG32_02610)	-	515938..517167 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
CPG32_RS02615 (CPG32_02615)	-	517370..517654 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
CPG32_RS02620 (CPG32_02620)	-	517661..518125 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
CPG32_RS02625 (CPG32_02625)	-	518289..518474 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
CPG32_RS02630 (CPG32_02630)	-	518544..519725 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=248239 CPG32_RS02600 WP_002461334.1 514103..515146(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_377]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=248239 CPG32_RS02600 WP_002461334.1 514103..515146(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_377]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911