Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   CO686_RS06230 Genome accession   NZ_CP023507
Coordinates   1245186..1247444 (+) Length   752 a.a.
NCBI ID   WP_084936956.1    Uniprot ID   -
Organism   Streptococcus oralis strain FDAARGOS_367     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1240186..1252444
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO686_RS06200 (CO686_06200) - 1240971..1241744 (-) 774 WP_096753625.1 HAD hydrolase family protein -
  CO686_RS06205 (CO686_06205) - 1241749..1242606 (-) 858 WP_049549837.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  CO686_RS06210 (CO686_06210) - 1242755..1243075 (-) 321 WP_049549838.1 TfoX/Sxy family protein -
  CO686_RS06215 (CO686_06215) - 1243109..1243843 (-) 735 WP_049549839.1 amino acid ABC transporter ATP-binding protein -
  CO686_RS06220 (CO686_06220) - 1243843..1244526 (-) 684 WP_001011622.1 amino acid ABC transporter permease -
  CO686_RS06225 (CO686_06225) - 1244718..1244948 (+) 231 WP_000443577.1 DUF1797 family protein -
  CO686_RS06230 (CO686_06230) clpE 1245186..1247444 (+) 2259 WP_084936956.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  CO686_RS06235 (CO686_06235) - 1247488..1248102 (-) 615 WP_065371690.1 GyrI-like domain-containing protein -
  CO686_RS06240 (CO686_06240) - 1248157..1249059 (-) 903 WP_049549842.1 YafY family protein -
  CO686_RS06245 (CO686_06245) - 1249236..1249688 (+) 453 WP_049549843.1 NUDIX hydrolase -
  CO686_RS06250 (CO686_06250) - 1249747..1250046 (+) 300 WP_000767203.1 DUF1827 family protein -
  CO686_RS06255 (CO686_06255) metK 1250118..1251308 (-) 1191 WP_049549844.1 methionine adenosyltransferase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83897.29 Da        Isoelectric Point: 4.9918

>NTDB_id=247864 CO686_RS06230 WP_084936956.1 1245186..1247444(+) (clpE) [Streptococcus oralis strain FDAARGOS_367]
MLCQNCKINDSTIHLYTNINGQQKQIDLCQNCYKIIKTDPNNTLFKGMTDLNNHDFDPFGDFFNDLNNFKPSSNNVPPTQ
SGGGYGGNGGYGPQNRGPLQTPPSQEKGLLEEYGINITEIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVG
KTAVVEGLAQKIVDGDVPYKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSAGDG
NMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETIIILKGVQKKYEDYHHVKYTDAAIEA
AANLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATREEDFEKAAYFRDQIAKYKEMQKN
KVTDQDTPIISEKTIEHIIEQKTNIPVGELKEKEQSQLIHLADDLKAHVIGQDEAVDKIAKAIRRNRVGLGTPNRPIGSF
LFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEK
AHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRFDGI
IEFKPLSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLENPSEK
DLKAVMTSNGNIQIKSAKKTEKTEEIASEIEE

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=247864 CO686_RS06230 WP_084936956.1 1245186..1247444(+) (clpE) [Streptococcus oralis strain FDAARGOS_367]
ATGCTCTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTGTATACCAATATCAATGGACAGCAAAAGCAAATTGA
TCTCTGTCAAAATTGCTATAAAATTATCAAAACAGATCCAAATAATACCCTCTTTAAAGGAATGACTGACTTAAACAATC
ATGACTTTGATCCTTTCGGCGACTTTTTCAATGATTTGAACAATTTCAAACCTTCTTCTAATAACGTCCCTCCAACTCAA
TCTGGTGGAGGATATGGAGGAAACGGTGGTTATGGACCTCAAAACCGAGGCCCACTTCAAACACCTCCTAGTCAAGAAAA
AGGACTCCTAGAGGAATATGGTATCAATATTACTGAGATTGCTCGTCGGGGAGATATTGACCCTGTTATCGGTCGAGATG
AGGAGATTATCCGCGTTATCGAAATCCTAAACCGTCGAACCAAGAACAACCCTGTCCTTATCGGAGAACCAGGTGTTGGT
AAAACAGCCGTTGTCGAAGGGCTAGCTCAGAAGATTGTCGATGGCGATGTTCCCTATAAACTCCAAGGCAAGCAGGTCAT
CCGTCTGGATGTAGTCAGTCTAGTCCAAGGAACAGGTATTCGAGGCCAATTTGAAGAACGTATGCAAAAGCTCATGGAAG
AAATTCGCAAACGCGAGGACATCATCCTCTTTATCGACGAAATCCATGAAATTGTTGGTGCAGGGTCAGCAGGTGATGGC
AATATGGATGCAGGCAATATCCTCAAACCAGCCCTTGCCCGTGGTGAATTGCAAATGGTCGGAGCCACTACTCTCAATGA
ATACCGTATCATTGAAAAAGATGCTGCTTTGGAACGCCGTATGCAGCCTGTCAAAGTTGATGAACCAACTGTCGAAGAAA
CCATTATCATCCTCAAAGGGGTTCAAAAGAAATACGAAGACTACCATCACGTCAAGTACACAGACGCTGCTATCGAAGCT
GCTGCAAATCTTTCCAATCGCTATATCCAAGACCGCTTCTTGCCAGACAAGGCTATTGACCTGTTAGATGAAGCTGGTTC
TAAGATGAATCTGACGCTGAACTTTGTTGATCCTAAAGTGATTGATCAGCGTTTAATTGAAGCTGAGAATCTCAAGGCTC
AAGCTACTCGAGAGGAAGACTTTGAAAAGGCTGCCTATTTCCGCGATCAGATTGCCAAGTACAAGGAAATGCAGAAGAAC
AAGGTGACCGATCAGGATACTCCTATCATTAGCGAGAAAACAATCGAACATATCATTGAGCAGAAAACCAATATCCCTGT
TGGAGAACTCAAAGAAAAAGAACAGTCTCAGCTTATCCATCTAGCAGACGACCTCAAAGCTCATGTCATTGGTCAAGATG
AAGCTGTCGATAAGATTGCTAAGGCCATCCGTCGTAATCGTGTTGGACTTGGAACTCCTAACCGCCCAATCGGAAGCTTC
CTCTTTGTCGGACCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTAGCCATTGAGCTCTTTGGTTCTGCTGACAG
CATGATTCGCTTTGATATGAGTGAATACATGGAAAAACACAGTGTGGCTAAATTGGTCGGAGCCCCTCCAGGCTATGTAG
GCTATGACGAAGCTGGTCAACTGACTGAAAAAGTTCGTCGCAATCCTTACTCTCTCATCCTTCTCGATGAAGTTGAAAAA
GCCCACCCAGATGTGATGCACATGTTCCTTCAAGTATTGGACGATGGTCGTTTGACTGATGGGCAAGGACGAACAGTTAG
CTTTAAAGATGCTATCATTATCATGACTTCAAATGCGGGTACCGGTAAGGCCGAAGCCAGCGTTGGTTTTGGAGCTGCTC
GTGAAGGTCGAACCAACTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTTGACGGCATC
ATCGAATTTAAACCTCTCAGCAAGGACAACCTTCTCCAAATCGTCGAACTCATGCTAGCGGATGTCAACAAACGCCTCTC
TAGCAACAATATCCACCTCGATGTGACAGACAAGGTCAAGGAAAAGTTGGTTGACTTAGGTTATGATCCAAAAATGGGGG
CACGCCCACTCCGCCGTACTATTCAAGACCATATCGAGGATGCCATCACTGACTTCTACCTTGAAAACCCAAGTGAAAAA
GACCTCAAGGCAGTTATGACAAGCAATGGCAATATTCAAATCAAATCTGCCAAAAAAACTGAGAAAACAGAAGAGATTGC
TTCTGAAATAGAAGAATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(646-720)

AAA lid domain (AAA_lid_9)

(290-387)

ATPase family associated with various cellular activities (AAA) (AAA)

(152-271)

AAA domain (Cdc48 subfamily) (AAA_2)

(475-638)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

94.624

98.936

0.936
  clpE Streptococcus pneumoniae D39

94.624

98.936

0.936
  clpE Streptococcus pneumoniae R6

94.624

98.936

0.936
  clpE Streptococcus pneumoniae TIGR4

94.489

98.936

0.935
  clpE Streptococcus mutans UA159

83.156

100

0.834
  clpC Lactococcus lactis subsp. cremoris KW2

76.026

100

0.763
  clpC Bacillus subtilis subsp. subtilis str. 168

52.615

86.436

0.455
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.485

83.378

0.404
  clpC Streptococcus thermophilus LMD-9

46.91

83.91

0.394
  clpC Streptococcus thermophilus LMG 18311

46.667

83.777

0.391
  clpC Streptococcus mutans UA159

46.508

83.777

0.39
  clpC Streptococcus pneumoniae Rx1

47.182

82.58

0.39
  clpC Streptococcus pneumoniae D39

47.182

82.58

0.39
  clpC Streptococcus pneumoniae TIGR4

47.182

82.58

0.39

Multiple sequence alignment