Detailed information NTG0246618

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: CMV25_RS08595
• Genome accession: NZ_CP023392
• Coordinates: 1727260..1729548 (+)
• Length: 762 a.a.
• NCBI ID: WP_096040208.1
• Uniprot ID: A0A290PZR3
• Organism: Lactococcus raffinolactis strain WiKim0068
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1722260..1734548

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CMV25_RS08585 (CMV25_08585)	dnaG	1724035..1725888 (+)	1854	WP_096040206.1	DNA primase	-
CMV25_RS08590 (CMV25_08590)	rpoD	1725891..1727021 (+)	1131	WP_096040207.1	RNA polymerase sigma factor RpoD	-
CMV25_RS08595 (CMV25_08595)	clpC	1727260..1729548 (+)	2289	WP_096040208.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
CMV25_RS08600 (CMV25_08600)	def	1729638..1730258 (-)	621	WP_096040209.1	peptide deformylase	-
CMV25_RS08605 (CMV25_08605)	uvrB	1730330..1732318 (+)	1989	WP_061775387.1	excinuclease ABC subunit UvrB	-
CMV25_RS08610 (CMV25_08610)	-	1732798..1733085 (+)	288	WP_061775386.1	lactococcin 972 family bacteriocin	-
CMV25_RS08615 (CMV25_08615)	-	1733148..1733768 (+)	621	WP_096040210.1	hypothetical protein	-

Sequence

Protein

• Length: 762 a.a.
• Molecular weight: 84054.81 Da
• Isoelectric Point: 4.7324

>NTDB_id=246618 CMV25_RS08595 WP_096040208.1 1727260..1729548(+) (clpC) [Lactococcus raffinolactis strain WiKim0068]
MLCQNCQLNEATIHLYTNVNGVKKQNDLCQNCYQIMKSGGPTNLFGGGANQGATNQSDANYNPFDDLFGTLGNNMNHPNG
RPDNATPPTQTGRGGNGGQPPRGRAGNAQPKGMLEDFGFNVTESARKGEIDPVIGRDQEITRVIEILNRRTKNNPVLIGE
PGVGKTAVVEGLAQKIVDGDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMKEISDRQDVILFIDEIHEIVGAGS
AGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQKRYEDYHHVKYTDE
AIEQAAILSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPQEIAKRIQSSEDAKNEALRSEDFEKAAHFRDQIAKLRE
LSKQELTDEETPVITEKDIESIIEEKTKIPVGDLKEKEQTQLINLADDLKAHVIGQDDAIDKISKAVRRNRVGLGKANRP
IGSFMFVGPTGVGKTELAKQLALELFGSQDSMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTEKVRRNPYSLILLD
EIEKAHPDVMHMFLQILDDGRLTDAQGRTISFKDTIIIMTSNAGTGKVEANVGFGAAREGTTNSVLGQLGDFFSPEFMNR
FDGIIEFKALSKDNLLQIVDLMLADVNAQISRNEIHLDVTQAVKEKLVDLGYDPKMGARPLRRTIQDHIEDAIADFYIEH
PEHKMLTADVIDDQIVIVNQSDDATTDGAIAETTADAGSADA

Nucleotide

• Length: 2289 bp

>NTDB_id=246618 CMV25_RS08595 WP_096040208.1 1727260..1729548(+) (clpC) [Lactococcus raffinolactis strain WiKim0068]
ATGCTCTGTCAAAATTGTCAGCTTAATGAAGCAACGATTCACCTCTACACAAATGTAAATGGTGTCAAAAAACAAAATGA
TCTCTGCCAAAACTGTTACCAAATCATGAAATCAGGTGGACCTACAAATCTTTTTGGTGGTGGTGCTAACCAAGGCGCAA
CCAATCAATCAGATGCTAACTATAATCCCTTCGATGATCTTTTCGGAACATTAGGTAATAATATGAACCATCCTAATGGC
CGACCAGACAATGCCACACCGCCAACACAGACTGGTCGTGGTGGTAATGGTGGTCAACCACCTCGTGGTCGTGCAGGAAA
CGCACAACCCAAAGGTATGCTAGAAGACTTCGGTTTTAACGTGACTGAAAGTGCCCGTAAAGGTGAAATTGACCCAGTCA
TTGGACGTGATCAGGAAATTACTCGCGTGATTGAAATTCTCAATCGCCGGACTAAAAATAATCCTGTTTTAATTGGCGAA
CCTGGTGTTGGTAAAACTGCTGTCGTTGAAGGCTTAGCCCAAAAAATCGTTGATGGTGATGTGCCACAAAAACTACAAAA
TAAAGAAGTTATTCGACTAGATGTTGTGAGTTTGGTTCAAGGGACAGGGATTCGTGGTCAATTTGAAGAGCGCATGCAAA
AATTGATGAAAGAAATCTCTGACCGTCAAGATGTGATTCTTTTCATCGATGAAATCCATGAAATCGTGGGTGCTGGGTCT
GCTGGCGATGGTAATATGGATGCTGGCAACATTTTGAAGCCAGCATTGGCTCGTGGTGAATTGCAGCTGGTCGGTGCAAC
AACGCTAAATGAATATCGGATCATTGAAAAAGATGCTGCGCTTGAACGTCGGATGCAACCAGTTAAAGTTGATGAACCTT
CTGTTGATGAAACGATTACTATTTTACGCGGGATTCAAAAACGTTATGAAGACTACCATCACGTGAAATATACGGATGAA
GCGATTGAACAGGCAGCCATCTTGTCTAACCGTTATATTCAAGATCGTTTCTTGCCTGACAAGGCCATTGACTTGTTAGA
TGAGTCTGGATCTAAGAAAAATCTGACCTTAAAATTCGTTGATCCTCAGGAAATTGCCAAACGGATTCAGTCTTCTGAAG
ATGCCAAAAATGAAGCCTTGCGTTCTGAAGACTTCGAAAAAGCAGCACATTTCCGTGATCAAATCGCCAAATTGCGAGAA
TTATCTAAGCAAGAATTGACGGATGAAGAAACACCAGTCATCACTGAAAAAGACATCGAATCTATCATTGAAGAAAAAAC
GAAGATTCCTGTAGGTGATTTGAAAGAAAAAGAACAAACGCAGTTAATCAATTTAGCCGATGACTTGAAAGCGCATGTCA
TTGGTCAAGATGATGCCATTGATAAAATTTCCAAGGCAGTCCGTCGTAACCGTGTAGGCCTTGGGAAAGCCAATCGCCCA
ATCGGTAGCTTTATGTTTGTCGGACCAACGGGTGTTGGTAAAACAGAACTTGCTAAGCAATTAGCCCTGGAGCTTTTCGG
TAGTCAAGACAGTATGATTCGATTCGATATGAGCGAATACATGGAAAAACACAGTGTGGCGAAGCTGATTGGTGCGCCTC
CTGGTTATGTTGGTTATGAAGAAGCAGGGCAACTGACTGAAAAAGTCCGTCGCAATCCTTATTCATTGATCTTACTGGAC
GAAATCGAAAAAGCCCATCCAGATGTTATGCACATGTTCTTACAAATCTTGGACGACGGTCGTCTGACCGATGCTCAAGG
TCGTACGATTAGCTTTAAGGACACGATTATCATCATGACCTCAAATGCAGGGACTGGTAAAGTAGAAGCCAATGTCGGCT
TCGGTGCAGCTCGTGAAGGCACGACAAACTCTGTCTTAGGTCAACTTGGTGATTTCTTCAGCCCTGAGTTCATGAACCGT
TTTGACGGCATCATTGAATTCAAAGCCTTAAGTAAAGACAATCTCCTGCAAATTGTTGACTTGATGCTGGCTGACGTTAA
TGCACAGATTTCAAGAAATGAAATCCATTTGGACGTAACTCAAGCAGTCAAAGAAAAATTAGTTGATCTTGGTTATGATC
CGAAAATGGGCGCTCGACCACTCCGCCGGACTATCCAAGACCATATCGAAGATGCCATCGCAGATTTTTATATCGAACAT
CCCGAACATAAAATGCTCACAGCAGACGTCATTGATGATCAAATCGTCATTGTCAATCAGTCTGATGACGCAACAACGGA
TGGAGCTATAGCAGAAACAACAGCTGATGCAGGCTCTGCTGACGCTTAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (156-275)

• AAA lid domain (AAA_lid_9) (294-393)

• AAA domain (Cdc48 subfamily) (AAA_2) (479-642)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (650-720)

3D structure

• AlphaFold DB: A0A290PZR3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	83.356	98.556	0.822
clpE	Streptococcus mutans UA159	76.209	100	0.765
clpE	Streptococcus pneumoniae Rx1	75.806	97.638	0.74
clpE	Streptococcus pneumoniae D39	75.806	97.638	0.74
clpE	Streptococcus pneumoniae R6	75.806	97.638	0.74
clpE	Streptococcus pneumoniae TIGR4	75.806	97.638	0.74
clpC	Bacillus subtilis subsp. subtilis str. 168	50.223	88.32	0.444
clpC	Streptococcus pneumoniae Rx1	48.232	81.627	0.394
clpC	Streptococcus pneumoniae TIGR4	48.232	81.627	0.394
clpC	Streptococcus pneumoniae D39	48.232	81.627	0.394
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.987	81.496	0.391
clpC	Streptococcus thermophilus LMD-9	44.932	86.745	0.39
clpC	Streptococcus thermophilus LMG 18311	44.629	86.745	0.387
clpC	Streptococcus mutans UA159	46.667	80.709	0.377