Detailed information NTG0024552

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: M5005_RS06245
• Genome accession: NC_007297
• Coordinates: 1220668..1221705 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes MGAS5005
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1215668..1226705

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M5005_RS06225 (M5005_Spy1260)	-	1216419..1217045 (+)	627	WP_010922497.1	prepilin peptidase	-
M5005_RS06230 (M5005_Spy1261)	rlmN	1217127..1218206 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
M5005_RS06235 (M5005_Spy1262)	-	1218210..1218830 (-)	621	WP_011285637.1	YutD family protein	-
M5005_RS06240 (M5005_Spy1264)	-	1219278..1220254 (-)	977	Protein_1192	LacI family DNA-binding transcriptional regulator	-
M5005_RS06245 (M5005_Spy1266)	sepM	1220668..1221705 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
M5005_RS06250 (M5005_Spy1267)	coaD	1221692..1222183 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
M5005_RS06255 (M5005_Spy1268)	rsmD	1222173..1222712 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
M5005_RS06260 (M5005_Spy1269)	asnA	1222835..1223827 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
M5005_RS06265 (M5005_Spy1270)	arcC	1224140..1225090 (-)	951	WP_010922501.1	carbamate kinase	-
M5005_RS06270 (M5005_Spy1271)	-	1225110..1226441 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=24552 M5005_RS06245 WP_010922499.1 1220668..1221705(-) (sepM) [Streptococcus pyogenes MGAS5005]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=24552 M5005_RS06245 WP_010922499.1 1220668..1221705(-) (sepM) [Streptococcus pyogenes MGAS5005]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693