Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   M28_RS05815 Genome accession   NC_007296
Coordinates   1136198..1138003 (-) Length   601 a.a.
NCBI ID   WP_011284935.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS6180     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1115946..1163001 1136198..1138003 within 0


Gene organization within MGE regions


Location: 1115946..1163001
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M28_RS05735 (M28_Spy1111) - 1115984..1117258 (-) 1275 WP_011284930.1 polysaccharide deacetylase family protein -
  M28_RS05740 (M28_Spy1112) - 1117353..1118780 (-) 1428 WP_011284931.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  M28_RS05745 (M28_Spy1113) ptsP 1118965..1120698 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  M28_RS05750 (M28_Spy1114) - 1120703..1120966 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  M28_RS05755 (M28_Spy1115) - 1121359..1121577 (+) 219 WP_002989242.1 redoxin NrdH -
  M28_RS05760 (M28_Spy1116) nrdE 1121597..1123756 (+) 2160 WP_002993430.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  M28_RS05765 (M28_Spy1118) nrdF 1124089..1125048 (+) 960 WP_011017933.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  M28_RS05770 (M28_Spy1119) - 1125110..1126336 (+) 1227 WP_021340858.1 chloride channel protein -
  M28_RS05775 - 1126432..1127588 (+) 1157 Protein_1076 IS3 family transposase -
  M28_RS05780 (M28_Spy1123) - 1127682..1128377 (-) 696 WP_002989227.1 CPBP family intramembrane glutamic endopeptidase -
  M28_RS05785 (M28_Spy1124) - 1128396..1129157 (-) 762 WP_002995753.1 DUF3169 family protein -
  M28_RS05790 (M28_Spy1125) - 1129154..1129369 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  M28_RS05795 (M28_Spy1126) alaS 1129730..1132348 (-) 2619 WP_011284933.1 alanine--tRNA ligase -
  M28_RS05800 (M28_Spy1127) prsA 1132735..1133790 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  M28_RS05805 (M28_Spy1128) - 1133853..1134560 (-) 708 WP_011284934.1 O-methyltransferase -
  M28_RS05810 (M28_Spy1129) - 1134626..1135822 (-) 1197 WP_002995765.1 L-lactate MFS transporter -
  M28_RS05815 (M28_Spy1130) pepF 1136198..1138003 (-) 1806 WP_011284935.1 oligoendopeptidase F Regulator
  M28_RS05820 (M28_Spy1131) - 1138016..1138978 (-) 963 WP_002995771.1 competence protein CoiA -
  M28_RS05825 (M28_Spy1132) - 1139273..1139989 (-) 717 WP_002989197.1 pseudouridine synthase -
  M28_RS05830 (M28_Spy1133) nagB 1140108..1140812 (-) 705 WP_021340997.1 glucosamine-6-phosphate deaminase -
  M28_RS05835 (M28_Spy1134) queA 1141014..1142042 (+) 1029 WP_011284937.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  M28_RS05840 (M28_Spy1135) - 1142049..1143269 (+) 1221 WP_002989189.1 DUF3114 domain-containing protein -
  M28_RS05845 (M28_Spy1136) - 1143383..1143973 (-) 591 WP_002989185.1 serine hydrolase -
  M28_RS05850 (M28_Spy1137) - 1143970..1144218 (-) 249 WP_002989183.1 serine hydrolase -
  M28_RS05855 (M28_Spy1138) - 1144274..1144429 (-) 156 WP_002989180.1 hypothetical protein -
  M28_RS05860 (M28_Spy1139) sodA 1144596..1145201 (-) 606 WP_002983977.1 superoxide dismutase SodA -
  M28_RS05865 (M28_Spy1140) holA 1145298..1146338 (-) 1041 WP_002989176.1 DNA polymerase III subunit delta -
  M28_RS05870 (M28_Spy1141) - 1146409..1148651 (-) 2243 Protein_1095 DNA internalization-related competence protein ComEC/Rec2 -
  M28_RS05875 (M28_Spy1143) - 1148632..1149294 (-) 663 WP_002983967.1 ComEA family DNA-binding protein -
  M28_RS05880 (M28_Spy1145) - 1149493..1150233 (-) 741 WP_021340996.1 lysophospholipid acyltransferase family protein -
  M28_RS05885 (M28_Spy1144) - 1150351..1151127 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  M28_RS05890 (M28_Spy1146) - 1151117..1151395 (+) 279 WP_011017953.1 GIY-YIG nuclease family protein -
  M28_RS05895 (M28_Spy1147) - 1151419..1153419 (-) 2001 WP_011284942.1 potassium transporter Kup -
  M28_RS05900 (M28_Spy1148) - 1153546..1155165 (-) 1620 WP_002989158.1 DEAD/DEAH box helicase -
  M28_RS05905 (M28_Spy1149) - 1155472..1157016 (-) 1545 WP_011284943.1 peptide chain release factor 3 -
  M28_RS05915 (M28_Spy1150) - 1157264..1157959 (-) 696 WP_011017956.1 TIGR02206 family membrane protein -
  M28_RS05920 (M28_Spy1151) murF 1158039..1159430 (-) 1392 WP_010922441.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  M28_RS05925 (M28_Spy1152) - 1159629..1160675 (-) 1047 WP_002989146.1 D-alanine--D-alanine ligase -
  M28_RS05930 (M28_Spy1153) recR 1160776..1161372 (-) 597 WP_002983939.1 recombination mediator RecR -
  M28_RS10015 (M28_Spy1154) - 1161419..1161610 (-) 192 WP_002983936.1 hypothetical protein -
  M28_RS05940 (M28_Spy1155) - 1162170..1162949 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69331.15 Da        Isoelectric Point: 4.7093

>NTDB_id=24491 M28_RS05815 WP_011284935.1 1136198..1138003(-) (pepF) [Streptococcus pyogenes MGAS6180]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFSVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=24491 M28_RS05815 WP_011284935.1 1136198..1138003(-) (pepF) [Streptococcus pyogenes MGAS6180]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTTCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

71.048

100

0.71

Multiple sequence alignment