Detailed information NTG0243297

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CGP99_RS10845
• Genome accession: NZ_CP022906
• Coordinates: 2059046..2060089 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 546
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2054046..2065089

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CGP99_RS10815 (CGP99_01954)	-	2054464..2055720 (-)	1257	WP_001795438.1	aminopeptidase	-
CGP99_RS10820 (CGP99_01955)	-	2055723..2055923 (-)	201	WP_000180461.1	DUF1128 family protein	-
CGP99_RS10825 (CGP99_01956)	-	2056070..2056534 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CGP99_RS10830 (CGP99_01957)	-	2056541..2056816 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CGP99_RS10835 (CGP99_01958)	-	2057094..2058311 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CGP99_RS10840 (CGP99_01959)	vraR	2058427..2059056 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
CGP99_RS10845 (CGP99_01960)	vraS	2059046..2060089 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CGP99_RS10850 (CGP99_01961)	liaF	2060086..2060787 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CGP99_RS10855 (CGP99_01962)	-	2060802..2061188 (-)	387	WP_001110179.1	hypothetical protein	-
CGP99_RS10860 (CGP99_01963)	map	2061405..2062163 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CGP99_RS10875 (CGP99_01964)	-	2062691..2063677 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
CGP99_RS10885 (CGP99_01965)	-	2064108..2064521 (-)	414	WP_001549145.1	hypothetical protein	-
CGP99_RS10890	-	2064550..2064660 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=243297 CGP99_RS10845 WP_001017131.1 2059046..2060089(-) (vraS) [Staphylococcus aureus strain 546]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=243297 CGP99_RS10845 WP_001017131.1 2059046..2060089(-) (vraS) [Staphylococcus aureus strain 546]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1