Detailed information NTG0242919

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CGP93_RS10050
• Genome accession: NZ_CP022897
• Coordinates: 1973976..1975019 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 128
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1968976..1980019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CGP93_RS10020 (CGP93_01850)	-	1969397..1970653 (-)	1257	WP_078103411.1	aminopeptidase	-
CGP93_RS10025 (CGP93_01851)	-	1970656..1970856 (-)	201	WP_000180462.1	DUF1128 family protein	-
CGP93_RS10030 (CGP93_01852)	-	1971003..1971467 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CGP93_RS10035 (CGP93_01853)	-	1971474..1971749 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CGP93_RS10040 (CGP93_01854)	-	1972027..1973244 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
CGP93_RS10045 (CGP93_01855)	vraR	1973357..1973986 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
CGP93_RS10050 (CGP93_01856)	vraS	1973976..1975019 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CGP93_RS10055 (CGP93_01857)	liaF	1975016..1975717 (-)	702	WP_106459782.1	cell wall-active antibiotics response protein LiaF	-
CGP93_RS10060 (CGP93_01858)	-	1975732..1976118 (-)	387	WP_001110179.1	hypothetical protein	-
CGP93_RS10065 (CGP93_01859)	map	1976335..1977093 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CGP93_RS10085 (CGP93_01860)	-	1977790..1978776 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
CGP93_RS10090 (CGP93_01861)	-	1978965..1979378 (-)	414	WP_025174475.1	hypothetical protein	-
CGP93_RS10095	-	1979407..1979517 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=242919 CGP93_RS10050 WP_001017131.1 1973976..1975019(-) (vraS) [Staphylococcus aureus strain 128]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=242919 CGP93_RS10050 WP_001017131.1 1973976..1975019(-) (vraS) [Staphylococcus aureus strain 128]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1